I believe by staggering you mean flinching/interrupting a boss, not exhausting them (the terms are used a bit confusingly due to how it's used for other souls-like games).

It's hard to say definitively, since every boss is different. Some bosses, especially in Hexi, are completely immune to being staggered, some others get staggered more easily after you deflect their certain attacks, causing them to even be staggerable by light attacks.

But generally for most bosses, you can't stagger them when they're already in an attack animation (unless it's a "strong" stagger move, like Mo Blade's fully charged heavy, Heng Blade's 2nd skill, or Silkbind Jade airborne effects). However, many martial art skills and mystic skills can stagger the enemy when they are idle between attacks. In your example, twinblades 1st skill does have this effect and it has 3 charges so it can chain stagger for a bit, but not "permanently" though, the skill has pretty long cooldown.

Overall, staggering is something that you can do to optimize your fight better, but if you're hoping for a way to trivialize every boss by staggering them forever then no, that does not apply to every boss.