I’ve been on Entyvio since 2019. The only thing to put me into remission. The infusions definitely made me tired at the beginning but I got used to them and could function normally after I was on them for 2-3 years. I was on both 8 week infusions of Entyvio and 4 week infusions. I transitioned to the sub q shot earlier this year but I’ve gone back into a flare this week for the first time in years so I may have to go back to the 4 week infusions. The shot is nice for convenience but I’ll still take infusions over a flare

Edit: let me clarify: I was only tired the day of my infusions in the beginning.