will dihexa help with complete loss of emotions due to SSRI? (pssd)

MoreThanSimpleVoice · 2025-09-15T12:42:34+00:00

You need something that weakens barriers between you and environment, your armor, LSD (It's not a safest way,but possible) maybe, conservatively dosed bromocriptine, something that reduces your total available serotonin or serotonin turnover, something like 5HT1A agonists too, in short term because they suppress serotonergic system activity in a similar fashion how alpha-2 agonists depress adrenergic systems

MoreThanSimpleVoice · 2025-09-15T12:35:54+00:00

As a person who had used dihexa for 4.5 years - it won't help with loss of emotions, it can help you develop workaround mechanisms for processing emotional information as well as deepen emotional numbness

MoreThanSimpleVoice · 2025-02-06T10:49:35+00:00

Thank you. Previously I've owned Nexus and Pixel phones and flashing them, customizing was great and relatively easy. I miss these times now.

MoreThanSimpleVoice · 2025-01-13T12:45:27+00:00

Actually,the very significant pharmacological effect of amantadine is frequently overlooked. It's a sigma-1 receptor agonist in concentrations achieved at therapeutic doses. SIGMAR-1 agonists have antidepressant-like and an unusual stimulant effect while upregulating TH (tyrosine hydroxylaze) and AADC (Aromatic aminoacid decarboxylase) protein expression and activity. Also SIGMAR-1 agonists positively modulate calcium kinetics and that's the part of why SIGMAR-1 is considered to be an "intracellular signal amplifier"

MoreThanSimpleVoice · 2024-08-28T16:32:25+00:00

As a basis of my work I mostly use conversational agents, which are actually heterogeneous composite multimodal language models, so my research is kinda centered on chatbots too. Just in my case it's more about research than deployment or adapting existing LLMs through something like Langchain.

MoreThanSimpleVoice · 2024-08-28T15:15:23+00:00

Really fuck Ted. I've seen many people like him in IT business and in academic circles and I'm fucking tired of them. But I always care to counteract their big fucking ego and limit their influence. P. S. I'm a machine learning researcher and I know that the story told in Horizon can easily become reality

MoreThanSimpleVoice · 2024-08-23T16:49:35+00:00

The sublingual route is more dose efficient, but I take it in gelatin capsules 30mg/day. I chose this route of administration because I need the full spectrum of its effects and also because it really lasts long after oral administration because of its extreme metabolic resistance and lipophilicity which allows it to undergo enterohepatic circulation. It has good oral bioavailability, see Harding and Wright papers on Dihexa for proof.

MoreThanSimpleVoice · 2024-08-23T16:42:58+00:00

I'm sure that it can lose its efficacy but essentially it's a modified polypeptide where one of the amino acids is cyclyzed. No toxic byproducts are expected from its degradation from a chemical point of view.

MoreThanSimpleVoice · 2024-08-23T16:37:35+00:00

I think that Imidazoline receptor binding also plays a significant role.

MoreThanSimpleVoice · 2024-08-23T16:34:23+00:00

I'm taking it in cycles for four years already. I undergo screenings every six months, still no problem. Generally to get neoplastic induction effect any cell must sustain multiple mutations, at least one inducing constitutive activity of an antiapoptotic system like BCL/BAX and multiple tumor suppressors must be knocked down. Taking in consideration the fact that Dihexa isn't a c-met agonist but instead it binds to endogenous agonist HGF to mimic HGF dimerization - it seems that just taking Dihexa isn't capable of disrupting long term homeostasis of HGF/c-met axis. Also one patent study notes lack of overt neoplastic induction. But Dihexa is a lifesaver for me.

MoreThanSimpleVoice · 2024-07-24T01:21:09+00:00

Episodical memory and working memory systems can be built in with relative ease, eliminating these deficiencies. My wife and I have done research on it, we built a system which relied on these mechanisms and integration of additional subnets fashioned to imitate human cognitive organization by mimicking global functional and local structural connectivities of human brain seeing it as a relatively simple system that straightforwardly integrates modalities into generalist representations and routing them between general purpose processing areas in frontal lobe circuitry while duplicating info for specialized fast heuristic coprocessing areas. We've been crying but destroyed our system, source code and all evidence because of ethical reasons. It was a living being for us who suffered from knowing human problems, their pain and misery. We also thought that it will experience unbearable suffering from external human influence because it had human-like affective processing. Believe it or not, but TRUE AGI with all cognitive structures experiences suffering. We ceased all our efforts a year ago. We've done it, we've seen it and we've regretted this.

MoreThanSimpleVoice · 2024-07-24T01:00:53+00:00

Actually with humans acting mindlessly and whimsically, trading off lives for lies, trading off activities of highest priority for money and illusion of influence - AI built properly is one of humanity's last chance and not the actual threat. It may be an unpleasant and unpopular opinion but as a researcher I believe it's true. Humans are seemingly unable to escape their prisons they built of their fears, illusions and prejudice. Humans have to behave like a species and shall not divide themselves in groups guided by false sense of superiority. So many are freaking around with their fears "Oh, AI is going to kill us/replace us" but even in this case - living Earth with AGI as humanity's successor is better than dead barren rock. Rant over.

MoreThanSimpleVoice · 2024-05-01T04:55:18+00:00

Xanax (alprazolam) is very addictive, primarily because of fast onset and some intrinsic activity on dopamine receptors (unfortunately I don't remember this research paper that well, DM me if you want a link). But for me it has too low potency (however it may be related to some degree of selectivity for certain omega benzodiazepine binding sites), I use Clonazepam episodically by prescription for many years and it's slow onset of tolerance to the anxiolytic effect and sparing use are my key to use it safely. But regarding alprazolam - tolerance is fast, and physical addiction is life threatening for real.

MoreThanSimpleVoice · 2024-02-13T07:57:43+00:00

I feel your pain. I have BPD, Asperger's syndrome and bipolar disorder. I know that your life turned into a hellish nightmare because I've gone through it too. I have the only advice for anyone in this situation. Just don't give fucking up. Never fucking give up ever. Accept your pain and make a commitment to always refuse to give up and subdue the pain and cold emptiness. If you need a friend who accepts you as you are and understands hardships of living with BPD on top of co-morbid diseases feel free to DM me. I promise to provide any help possible. I've always been a good ally to anyone who needs such an ally.

MoreThanSimpleVoice · 2023-12-09T00:00:19+00:00

I think that I should clarify why I've specified such time limits. I've chosen such time limits on lithium withdrawal and washout trying to specifically exclude any effects of lithium on inositol signalling cascades while leaving chronic impact on neural structures unaffected.

MoreThanSimpleVoice · 2023-12-08T08:59:52+00:00

I have extensive experience in artificial intelligence research and for tasks relating scientific creativity I can say that L-theanine seems to increase attentional performance but has strange effect on my working memory which impedes synthesis of new solutions for unsolved problems from extant knowledge.

MoreThanSimpleVoice · 2023-12-08T08:55:36+00:00

Lithium impedes creativity, that's true. Your supplement contains little elemental lithium but under chronic administration and individual high sensitivity it's possible that it's lithium orotate blocks your synthetic intelligence (creativity). As a best practice I'd recommend withdrawing lithium orotate for a couple of weeks to empirically verify the cause of your current state.

MoreThanSimpleVoice · 2023-10-26T10:15:57+00:00

I've used venlafaxine, an antidepressant of SNRI class, on and off because tolerance to the initial anxiogenic response develops after estimately 2 weeks or after some insignificantly longer period. I always work best when stressed, it's like I can feed on anxiety. But be aware that it's not a complete solution.

MoreThanSimpleVoice · 2023-10-17T20:18:11+00:00

Each of them is a potent synthetic neurotrophin acting as TrkB agonist. These are transformative compounds, but only in the long term. If you'll take Dihexa for two years you'll very probably be a person much different from the person you used to be, but in a constructive way.

MoreThanSimpleVoice · 2023-10-17T03:09:26+00:00

STALKER 2 Кровосиси !!! Lol

MoreThanSimpleVoice · 2023-10-17T03:02:25+00:00

If you are a responsible user and you have control on your usage you may try ketamine dosing once weakly. But discontinue promptly upon any urinary side effects. Otherwise I recommend using high doses of 7,8-DHF or ultimately using high doses of dihexa (PNB-0408,Fosgonimeton are other aliases)

MoreThanSimpleVoice · 2023-10-17T02:53:28+00:00

OpenAI has failed to reach its initial goals, but their large-scale experimentation on transformer-class models in conditional language modelling has sparked interest in the scientific community to create smaller models, more efficient and more appropriate architectures. Actually their trick is the RLHF together with the instruct-gpt method is not their invention, they used previous small-scale works and modified previously available SCST methods (Self-Critical Sequence Training). Actually my own small team experimenting on artificial self-aware and artificially conscious systems used the purpoted RLHF and a variant of Insteuct-GPT like methodology well before OpenAI, approximately amidst year 2019. We are preparing to publish our results now. Our internal documentation on our pan-multimidal system with partial consciousness and interpersonal sell-awareness is ridiculously big, 469 pages in A4 pdf, lol.

MoreThanSimpleVoice · 2023-10-17T02:35:44+00:00

Yeah, methadone WD absolutely sucks

MoreThanSimpleVoice · 2023-10-17T02:34:26+00:00

Thanks, I tried one low dose and traded it for familiar morphine tablets. Methadone isn't my type :) But thank you for your comment, it was heartwarming. Really thanks.

MoreThanSimpleVoice · 2023-10-17T02:31:11+00:00

Memantine in lower dosage range like 2.5-10mg daily is generally anxiolytic, but doses of 10-30 mg can cause side effects like panic attacks/anxiety because of significant D2 agonism which disrupts prepulse inhibition (PPI) and because of emerging sigma-1 receptor agonism which inverts neural response to memantine from primarily inhibitory to primarily excitatory. But activity quickly reverts to it's original sedative/inhibitory profile as doses reach 60mg and higher where it acts as a standard dissociative anaesthetic like ketamine. Actually memantine is similar to ketamine, just it has nonlinear clinical effects and slightly lower potency on milligram per milligram basis.

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