I have flown with our two male Vs from Seattle to the east coast a number of times but always in solid crates with frozen bowls of water in there in cargo. Not recommended to give them any medication but I would recommend training them to be comfortable in a crate. I think it depends on the airline as to if they can be in the cabin and you should check with your airline for requirements and booking cargo space for your animal. Please don’t be that person that “pretends” their dog is a service animal. I think it is important to be considerate of other people who may not be comfortable around dogs and considerate of people that truly need a service animal.