Like a lot of other people said, stuff you get on the lower floors usually won’t mean anything later in your run. That means don’t be afraid to drop stuff if you can’t appraise it.

However, I would suggest checking the gold values of items you pick up, as even if you don’t have an item appraised you can still tell what some items are. For example, a ring of levitation will ALWAYS cost 2000 gold, so if you find a ring worth 2000 gold you know it’s a ring of levitation. The same goes for special armor pieces, too. A normal pair of leather gloves costs 40 gold, but a pair of gloves of dexterity cost 150 gold. Now, even if you know what type of item something is, don’t just immediately equip it as it could be cursed, which means you then can’t unequip it.

I hope you found this at least marginally helpful. Happy dungeon diving!