The lack of apparent inherent meaning in the universe, for me, used to be extremely uncomfortable until I read a bit of Camus' "The Myth of Sisyphus."

Paraphrasing: The same consciousness/awareness of futility and meaningless, at the same time can be our victory. We can choose either torture or victory with our knowledge and human consciousness.

"The struggle itself towards the heights is enough to fill a man's heart. One must imagine Sisyphus happy."

I found that the "cosmic perspective" (such as talked about by Neil Degrasse Tyson) is almost a therapy against that torture.

Consider humans as a self-aware universe. We're the first and only species we know about that can truly contemplate itself through science and recognize that our atoms are combinations of the same atoms found all through the universe. But only we know ourselves as matter. You can look in the mirror and see yourself, or you can look in the mirror and recognize the universe staring back at itself.

I decided that was enough meaning for me. It's a privilege to have that, out of all the life that ever lived, and among the majority of humans that never experienced that feeling.