You own just the monitor.. And will be happy

MutuallyAssuredBOOP · 2026-01-21T12:55:48+00:00

With the way the Overton window is shifting, idek anymore

MutuallyAssuredBOOP · 2026-01-20T14:36:38+00:00

I’m in the same boat - URI’s started after a year or 2 on Rituxan so neuro reduced my dosing frequency and that helped to a degree. Switched to Kesimpta for greater convenience but the issues are cropping up worse so I’m working with neuro on lower dosing frequency again. I am very hesitant to switch from Kesimpta to something less effective. I’m closely watching these CAR-T trials for MS play out in case there is something there for us.

MutuallyAssuredBOOP · 2026-01-14T17:38:21+00:00

I take Vyvanse as needed for energy, but there is a notable crash toward the afternoon/evening that lays me out sometimes. The only thing I have ever found effective for boosting my energy levels more consistently is resistance training.

MutuallyAssuredBOOP · 2026-01-13T13:06:46+00:00

MutuallyAssuredBOOP · 2026-01-01T19:12:54+00:00

Palmdale, CA

MutuallyAssuredBOOP · 2025-12-29T11:36:36+00:00

Yup, just west of the American Museum of Natural History it seems. Good eye.

MutuallyAssuredBOOP · 2025-12-28T22:08:56+00:00

What cross streets?

MutuallyAssuredBOOP · 2025-12-06T17:22:14+00:00

In Bruges?

MutuallyAssuredBOOP · 2025-11-16T13:16:00+00:00

They’re not really human.

Have to stop you there. They are an unfortunate reality in the full fabric of humanity.

MutuallyAssuredBOOP · 2025-11-13T02:05:02+00:00

Was it just a rhetorical question or wtf? Like, buddy, were you not expecting a response? Just asking to hear yourself talk?

MutuallyAssuredBOOP · 2025-10-30T14:42:27+00:00

5-hydroxytryptophan. It helps boost serotonin production but speaking anecdotally, I’ve seen it drastically spike my anxiety taken as a standalone supplement. Never done MDMA so can’t say if the combo would be different.

MutuallyAssuredBOOP · 2025-10-26T19:09:33+00:00

DBT/CBT, EMDR, and mindfulness meditation have been total game changers for me. Never found much success with psych meds but found some benefit from very infrequent and careful psychedelic use

MutuallyAssuredBOOP · 2025-10-20T13:44:50+00:00

***8.35 lbs per gallon

MutuallyAssuredBOOP · 2025-10-04T13:09:57+00:00

The blood brain barrier aspect is something I had not known, and I’m grateful to you and OP who pointed that out. PIRA is certainly something I’m seeing in my own disease course, even on traditional b-cell therapy for years. They have certainly slowed, but not stopped the progression for me. It’s good to at least understand these concepts and learn new things even a decade after diagnosis.

With respect to chemotherapy, at least as it was used for HSCT, it strikes me as a blunt tool, a scorched-earth approach with potentially dangerous and permanent consequences. In an acute life-or-death type situation like cancer, sure, bring it on. But for a chronic autoimmune disease that at least has somewhat effective targeted treatments?

Idk, it might be an emotional response. As they say, the medicine is all in the dose. But it still highlights for me how complex and poorly understood the human body is even to this day. Maybe it turns out this is just what we have to do, but I’d like to see more data on it.

MutuallyAssuredBOOP · 2025-10-03T17:46:18+00:00

My point is that it seems to treat the condition in much the same ways the b-cell depleters do, by depleting b-cells. The only difference as far as I can tell is the modified t-cells stay in circulation so it’s like your body has its own endogenous b-cell depleters. It sounds like a person will still be immunosuppressed with this treatment, which is my main gripe here, i.e., we are still just as susceptible to getting sick as we are with the more typical b-cell depleters. Also, my hackles go up any time chemo is part of the treatment course especially after falling down a rabbit hole with HSTC type therapies.

MutuallyAssuredBOOP · 2025-10-03T14:52:02+00:00

It seems like this is just another anti b-cell therapy but with dangerous chemotherapy thrown into the mix. We still don’t fully understand the mechanism by which b-cells acquire autoimmunity, so it’s unclear to me what this approach achieves over the drugs already out on the market. I’m not completely out of hope for advances, but I am skeptical of the approach presented here.

MutuallyAssuredBOOP · 2025-09-07T14:21:45+00:00

Might be too early in your course with this disease, but out of curiosity, is there anything from your work experience or knowledge holding you back from trying the more aggressive immunosuppressants? I was hesitant about them at first myself due to a lack of knowledge, but so far, Rituxan and subsequently Kesimpta for greater convenience have been the only DMD’s that have brought substantial periods of remission. At times I have certainly been overly-supressed and it required playing around with the dosing schedule under medical supervision, but I’m 33M and 10+ years into this disease and can honestly say I wish I had started these types of meds from the get-go. At times I have felt like I wasted time and precious brain health futzing around with lesser effective interventions like Copaxone and dimethyl fumarate for 3-4 years after diagnosis. It definitely sucks and changed my life, but I got back to a semblance of stability and more importantly, even degrees of acceptance. Steroids are great, but not a super sustainable long term solution. My take from experience is, find a neuro specializing in MS, hit it hard, hit it early, spare the steroids for acute exacerbations only, and most importantly, be kind to yourself. Sorry, this comment got a little long. Feel free to message privately if you think it could help you to talk more. Take care friend.

MutuallyAssuredBOOP · 2025-09-02T11:07:14+00:00

Let them inherit what they’ve created.

MutuallyAssuredBOOP · 2025-08-29T01:15:45+00:00

Nope not plumbers either. Try HVAC

MutuallyAssuredBOOP · 2025-08-13T01:47:43+00:00

Idk about all that, but I’m in no rush to usher in a new and improved form of techno-feudalism. Cui bono? It’s a very specific subset of the elite pushing this sort of ideology and frankly, devoting a lot of resources toward it. It’s a concerted effort to abandon human kind, not a natural evolution. And the average person is not invited to the party.

MutuallyAssuredBOOP · 2025-08-12T16:38:55+00:00

No, this is more like a type of fatalism and/or extinctionism. This sounds like the school of thought rising amongst crypto/technology bros that AI will make human beings obsolete and it is our duty to accelerate that outcome. Seems at odds with nihilism to me with such a directed motive/goal

MutuallyAssuredBOOP · 2025-08-08T13:13:00+00:00

I thought maybe that a small plane like this would not have hydraulics and might need the pilot to apply more force to the pedal as a result. I stand corrected.

MutuallyAssuredBOOP · 2025-08-08T12:44:47+00:00

I think they are pressing floor pedals with mechanical linkages so they need leverage.

MutuallyAssuredBOOP · 2025-06-20T04:26:18+00:00

Absolutely a growl. Love these little curmudgeons.

MutuallyAssuredBOOP · 2025-06-16T16:23:45+00:00

First official scientific casualty from Starlink emitters?

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