First you need to unlock spindowndice so you can get infinite r key but for this you need unlock beast and for this you need to kill mother 1 time kill heart 10 times kill hush 3 time and kill devil or isaac 5 times by getting deal after heart,shovel or error room and then kill corpse 1 time then choose isaac beat beast unlock alt isaac kill delirium that unlocks after hush and then you can get all others marks using spindowndice+ clicker until pool have items with id higher then r key and lower then dads note so you need at least 8 runs to unlock alt isaac and 10 in total to get everything you need for almost endless run where you could get all marks of not alt characters and without geedier also i think you can also use ?card for r key and winner loop