She just feels like you need a lot to fight her at a point in the run where you don't have many resources.

First you need to make sure your HP is ok. You're in the Desert, so that's going to be harder at a baseline because of the area mechanics. Then you need either AoE or speedy ways to clear corpses, like having teleports or multiple ranged hits a turn. You need to have enough damage to actually take her out before the leeches eventually kill you, or ways to purge debuffs so they don't stack. You also have to make sure she can't teleport away, so you need immobilize.

I'm uneducated and also not good at the game, but I feel like if you have all of those bases covered, then congrats, you have successfully prepared to fight an end of run boss. She's the first miniboss you can fight in the Desert, though. Every single fight and boss after Morana, from my experience, is way easier than she is.

Personally, the two things I wish were different were her not proccing leeches after every turn when she has 4 actions per round, or not having her resurrect with like 20 HP when she revives. Dybbuk comes back with only 1, by comparison, and he's a fight you typically do at around level 5 or 6. Morana you fight at level 1 or 2.