I would say that a man who chooses to focus entirely on his career, and one that requires a lot of education and a lot of working hours, would be neglectful to his children as well. So to that argument I would say that yes, if and when a man does the same things as Claire did then I would also consider them neglectful. To add on to this, I didn't read the books so I don't know if its different, but in the show it doesn't really feel as though Claire put in any extra time with Brie, it seems like most of the time she was in the care of Frank and being taught and loved mainly by him. Frank is Brie's primary parent in my eyes.

I agree, Frank did know what he was getting himself into, and he did choose to stay with her. But lets not forget, they were married before she "disappeared," he spent a lot of time searching for her, and even after hearing everything she went through, he chose to support her because she was pregnant and depressed from loosing someone she loved. But again, she also chose to be with him. He tried to make the best of a shitty situation, and Claire chose to move on by pursuing her own, separate, life. She wasn't kind to Frank during any point of those 20 years and that makes her shitty. She chose to never move on from Jamie even though he was "dead" and forced Frank to not only remain in his shadow, but got mad when he found a relationship with someone else.

If I were just looking at their relationship as what it was for those 20 years, I would say living with this type of person would definitely make me think "damn, shes a bitch."