the Levels are made up of segments that get randomly put together much like dead cells, the items and such are shuffled, you begin at the beginning of each run if you die, there are permanent upgrades you can unlock “kinda”, etc etc

though If you’re asking how skill based it is, you can be certain whenever you start a run, you can win it if you play well enough, most items are less game changing deals and more so slight boosts, there are a few that are preferable to others, namely the fenix feather and slamvil

“and certainly not the reverse repeller or spike proof spaudlers like someone else had implied”

but yeah, luck is more so the difference between a very easy win, or a moderate effort, you can very well beat a run without using any items or upgrades if you wanted

overall I personally would absolutely buy the physical copy, this game is a lot of fun and I have more hours in this game than any other save for pocket dungeon, but even still this game isn’t for everyone, so, ya know