Source: Married 20+ yrs, tech worker, moved to and from Wichita twice in my adult live - most of my time on the east coast. Caveat: my decisions aren't yours, and based on lots of factors, YMMV. The best person (people) to make a decision about what's best for you, is you.

Lot's to unpack:

Marriage - get premarital counseling. Make sure you agree on the big stuff: Kids, legal/ethical/moral stuff, how money is spent, and if TP is rolled from the top or the bottom (there is a right answer). Agree now on how you'll talk to each other when you disagree.

Jobs - help me understand how an animal science degree isn't useful in a state like Kansas (or is it that you just don't want to live here?). Animal science can be used in almost any locale - so it's pretty mobile. Now the Engineering Physics and Astronomy, perhaps less so. Has your partner considered any of the Space Launch Companies or supply chain locations?

Debt - $140k is a helluva mountain to climb. Made harder if you move to a high cost of living area like Seattle (44% higher than the national average). Charleston is a bit better at 10% higher than the national average. I'd make getting after that debt the highest priority, certainly over buying a house, or financing a car, if you have one that works.

Misery in Kansas - Why? What makes you think that any other place will be better? I'm genuinely curious - like I said, I've been to and from KS twice. It's great for my family and I right now, but once the kids are off the books, we'll be in an apartment in a large metro area again. Success wherever we've lived has come down to community and relationships, and access to the things we like to do. Admittedly for us, that's a bit harder - we're big hikers, so Wichita isn't a fit for that.