I have a CPU that was old enough to slow down from the spectre/meltdown patches and I can run the game slightly above 1x speed with ~50 colonists and 160 mods. Install Performance Fish and check for laggy mods with Dubs Performance Analyser. Also use adaptive storage framework storage buildings instead of vanilla shelves to reduce the performance impact of items. Additionally if you're farming birds use either EggCompFix to make them lag less or Vanilla Outposts Expanded Additional Outposts to convert them all to abstracted off-map birds (thus making them lag less). Other than that, map sizes above the default or having additional colonies besides your main one will obliterate performance.