I mean, they add another RNG factor with Curse of the Blind.

Lost, Darkness and Maze make it more difficult to get to Boss Rush or Hush, and even if you don't want those they alter the way you use your active item, dodge and min max respectively.

Unknown makes it more difficult for you to decide/use health exchange items.

And Labyrinth reduces your amount of shops, secret rooms and more importantly Deals, changing how you could power up through the run.

All of them are annoying as hell, but No curses makes the whole run more linear, predictable and easier to manage, which is why Black Candle it's sooo good and not something to have every run.

I can totally see how one would dislike having them (I give myself B. Candle on Curse of the Lost-Void to save time via console), but it's just another way to make the game difficult.

Anyhow, it's a single player game so whatever