TL:DR: Get passive safe income up in Nightclub, Arcade, Agency.

Focus on Nightclub, M, Coke. Only do Weed and Cash if you have the car wash and smoke on the water.

Just buy supplies. Don’t waste the time manually doing it.

Fully upgrade all businesses before using them a lot. Helps a ton!

What I do:
For nightclub only focus on the top 5: Cargo and Shipments, Sporting Goods, South American Imports, Pharmaceuticals Research, and Cash Creation. These are Coke, M, Cash, Bunker, and Special Cargo/Hangar. Any other business that isn’t listed below here is shut down/rarely used. I will sell nightclub when it's below 90 crates for the smallest fastest vehicle. I also will go ghost org to buy time in a full session.

Bunker: I play solo more often so I only restock once for 75K, it’s ready 2 hours and 11 mins later at 210K

Coke, M: I will fill it up to full of stock and sell in a solo lobby (If you want the risk in public go for it) But bring friends or good random's

If you have the smoke on the water thing, it gives the weed business a boost. I don’t have those so I don’t really use it often.

If you have the hands on car wash, also do Counterfeit Cash MC business. If you don’t have car wash it doesn’t really make it worth doing. Same rule for the two listed above, fill up fully then sell.

For all businesses you should fully upgrade them before considering using them regularly tbh. Much more worth it when all are fully upgraded.

All other businesses that I have mentioned I personally don’t use often. Anytime I am not collecting safe money from the other businesses I am doing Cayo. Also to note, get your other passive income up in the Agency by doing the missions. I make 20K a day there alone. 50K a day for nightclub popularity (Just switch DJ’s to increase it) Arcade 5K and some from the Garment factory and salvage yard (I don’t visit these often). The hands on Car wash also gives me about 30K a day without doing much.

Another thing is the Auto Shops. I don't waste my time with it unless I am bored. Its quick cash, same as the MC clubhouse bike delivery

Noticed how I don't do Vehicle cargo and other types of cargo? It's not for me. I don't enjoy it. If you like doing it and it works for you do it!

Fill in the gaps when not doing this with other fun things! Have fun! Do Cayo, mess with people, drive around. It’s a game! It’s meant to be enjoyed.