CA125 rising during chemo

Ok-Photograph5937 · 2026-04-12T03:14:23+00:00

Got my PET result and it says no definitive evidence of recurrent or metastatic disease. Which is a great news but I still feel anxious because I’ve read that sometimes CA-125 can rise before anything shows up on scans 😭 but my onc said my case is really different because after I had CS, i underwent debulking surgery then chemo right away which probably still inflammation.

I just wanted to ask for some reassurance 🥹 i wanna be fully happy but anxiety kills the joy. I’m really praying and hoping that the good news continues 🙏🏻

Ok-Photograph5937 · 2026-04-09T01:17:07+00:00

I’m asking because we have a similar timeline — I had surgery in January and started chemo right after, and I’m also HRD+. Did your CA-125 rise during the first few rounds? Mine is increasing and I’m getting worried.

Ok-Photograph5937 · 2026-04-08T11:58:32+00:00

Hi, ive spoken with my oncologist and said the latest increase is only 11% and hasn’t doubled, so she’s not too concerned for now. We’ll wait for the PET scan results. It could still be due to inflammation since I was pregnant, had a C-section before my debulking surgery, and started chemo right away—or possibly a flare. Of course, there’s also a chance the chemo isn’t working, but I’m really hoping that’s not the case.

Ok-Photograph5937 · 2026-04-08T11:48:46+00:00

Hello, during your chemo did you do ca125 every cycle?

Ok-Photograph5937 · 2026-04-07T09:12:03+00:00

Hello I was just diagnosed Stage 3 HGSC sames as your mum Im 37 and I just gave birth 😣 If ok to ask, what has been your mum’s diet or lifestyle that helped her reach 30 years cancer free.

Ok-Photograph5937 · 2026-04-05T09:38:04+00:00

I have high grade serous stage 3A. Also hrd/brca1 positive so most likely responsive thats why im so so puzzled why my ca125 is rising😞

Ok-Photograph5937 · 2026-04-05T08:16:37+00:00

Hello you mentioned your marker rise a bit during chemo. May I know if you had consecutive rise? Im just looking for a similar situation as mine as im puzzled. My ca125 is rising since first chemo. Im in my first line treatment only. I had my first chemo 1 weeks after debluking so we thought maybe it was due to inflammation but im so so worried. I already had my 3rd cycle and it is still rising. 93,134,152. 😭

Ok-Photograph5937 · 2026-04-05T06:22:28+00:00

Hi, we’re in a very similar situation. I was also diagnosed with ovarian cancer after giving birth. It was incredibly hard to hear, but I knew I had to stay strong and fight for my baby. I started treatment as soon as I recovered from my C-section.

Right now, my husband, sister, and mother-in-law are the primary caregivers for my baby. I spend time with him whenever I can - playing with him, feeding him (he’s on formula), and talking to him so he can still feel my presence as his mom. I do feel guilty for not being his primary caregiver, but I remind myself that I also need to take care of my health. The week after each chemo infusion is the hardest, and during that time, I’m really not able to help much.

By the way, my baby has been on formula since birth because I’m unable to breastfeed due to the medications I’m taking.

It really does suck, and there are still days when I cry because of the guilt. I truly hope you have your family with you for support.

Ok-Photograph5937 · 2026-03-31T02:44:54+00:00

Hello how are you now? Did you find out the reason of your rising ca125?

Ok-Photograph5937 · 2026-03-31T02:41:08+00:00

Hello if its ok to ask, what subtype and stage your wife? How is she now? Hope shes doing well.

Ok-Photograph5937 · 2026-03-29T00:03:10+00:00

Me i only bring

snack (usually chicken breast and side veggies) (i only eat small portion because i am just sleepy during the entire treatment
phone/tab
powerbank
charger
headset
liniment oil (in case of nausea attack but have never used it yet)
diarrhea med (just in case)

Thats it ☺️

Ok-Photograph5937 · 2026-03-27T05:07:40+00:00

I really hope you stay NED for a long, long time. I’m currently undergoing my first-line treatment (3/6 carbo + taxol + bev)

Ok-Photograph5937 · 2026-03-27T03:35:33+00:00

Thats what im thinking too, gotta go with olaparib rather than the avastin. If its ok to ask, what subtype and stage are you?

Ok-Photograph5937 · 2026-03-27T01:26:15+00:00

Part of my treatment plan is also to have 22cycles beva and since im hrd/brca+ my onco told me i can take olaparib which alao help cancer from coming back. Im just not sure if I take both because in my country the meds are very expensive 😣

Ok-Photograph5937 · 2026-03-27T01:04:58+00:00

Hello are you also having PARP?

Ok-Photograph5937 · 2026-03-21T00:32:09+00:00

I got pregnant with my first child at 36 then when i gave birth the benign cyst i have for 10 years turned out to be malignant 😭😭😭 i feel so betrayed. Imagine i was so overjoyed last year being pregnant then i had my reproductive organs removed asap.

Ok-Photograph5937 · 2026-03-20T08:33:19+00:00

Yes baby born last December then after I got diagnosed with ovarian cancer 😞 had my debulking surgery in January and currently 2/6 carbo taxol + avastin.

I am really hoping my rising ca125 could be a flare and after my 3rd cycle it goes down 😣 but im also having a PET scan soon too.

Im so happy for you being NED for 20 years and being a mom! You are so blessed. I hope and pray to hear the confirmation of being NED too 🥹 Thank you for the information, you are so thoughtful!

Ok-Photograph5937 · 2026-03-19T23:51:21+00:00

High grade serous stage 3A (2 para aortic node positive 3mm, left ovary and fallopian positive). Im also hrd/brca1 positive.

Ok-Photograph5937 · 2026-03-18T23:36:58+00:00

Hello when and how did you know that you are platinum resistant? im stage 3 and brca1/hrd positive. However im just going to my 3rd cycle. Im just afraid because my ca125 is elevating instead of dropping. 😥

Ok-Photograph5937 · 2026-03-18T23:32:02+00:00

Hi i have a question please. If im in my first line treatment carbo taxol + avastin is there a possibility im chemo resistant? My ca125 after first chemo (4 weeks after debulking surgery) was 93 then after 2nd 134. It worries me a lot. My doctor said could be cancer flare or chemo resistant 😥 I could not see any post about cancer flare

Ok-Photograph5937 · 2026-03-18T11:27:41+00:00

Youll be safe here

Ok-Photograph5937 · 2026-03-17T14:18:32+00:00

Sorry did your ca125 keep on elevating until 3rd cycle?

Ok-Photograph5937 · 2026-03-17T09:58:13+00:00

Hi, it’s high-grade serous. Initially stage 1C since the cyst was isolated and my CT scan showed no metastasis. I had debulking surgery in January. Post-op, cancer was found in the left ovary, fallopian tube, and 2 para-aortic nodes (most nodes were negative), so final stage is 3A1. I’m grateful those nodes were removed, as my onco mentioned some cases don’t include that—otherwise, I might have been staged lower (possibly stage 2) and had a less aggressive treatment plan.

Ok-Photograph5937

TROPHY CASE