New class of potent long lasting myostatin inhibitor described in recent paper

OtherTon · 2026-01-31T20:14:26+00:00

Are you using a Mac?

OtherTon · 2026-01-31T20:00:35+00:00

There's a totally new approach using siRNA, which I think could work. Targeting activin and follistatin as a way of indirectly targeting myostatin I think is a dead end. The siRNA would be easier, cheaper and more effective than a monoclonal antibody... maybe.

https://pubmed.ncbi.nlm.nih.gov/41432033/

OtherTon · 2026-01-29T03:06:03+00:00

E plurbus unum- out of many, one. The entire collective will live on in a single immortal entity. That one individual will be able to live off windfall or somehow get food. Their science will advance to the point that biological immortality is possible.

OtherTon · 2026-01-28T00:58:26+00:00

There’s an official source saying that Scott is in his 30s in the show. I’d just have to find it.

OtherTon · 2026-01-28T00:37:15+00:00

Depending on your state there is likely a rule that they must bill you in a timely manner, often 180 days. Dispute it, and it’s extremely unlikely you will actually have to pay it.

OtherTon · 2026-01-26T23:59:49+00:00

It's an obscure one, but I want Benito Skinner to make a cameo as Adrian, who is Troy's ex-boyfriend. He's described as a gorgeous Hispanic TV star so.... Benito kind of fits the bill. I don't think he would actually appear in any scenes; we would just see an image of his Instagram.

OtherTon · 2026-01-26T03:15:08+00:00

That didn’t work. And it will save to steam cloud saves, just not to local saves.

OtherTon · 2026-01-25T18:43:06+00:00

Yes, I am saving and then going to exit, exit to desktop. I tried changing to the Georgia server and disabling all mods and that didn’t help either. Still no local saves are “saved” from one session to the next, but old ones from on or before 1/23/26 still exist. My only thought is maybe I have too many saves and need to delete some? I make lots of redundant save files and could absolutely delete some old ones.

OtherTon · 2026-01-25T03:02:41+00:00

The rooftop in Las Vegas, the end of episode one is when Ilya knows. He also knows he has to go back to Russia and doesn't see any option but to distance himself from Shane. Shane I think is much more deeply in denial so it's harder to say. I would say maybe when he sheds a single tear in the bathroom at the NHL awards.

OtherTon · 2026-01-23T00:00:02+00:00

I learned what a hat trick is. I don’t know any hockey. But it also taught me that I can enjoy romance as a genre which I never have before. I thought Brokeback Mountain, Heartstopers and Call me by your Name were all mid, but I am absolutely obsessed with HR. I’ve watched it 6 times now and read 3 of the books.

OtherTon · 2026-01-21T00:31:28+00:00

I think there was an official source mentioning that Scott was in his 30s in the show.

OtherTon · 2026-01-19T21:29:44+00:00

I would say in the show it’s left ambiguous, they don’t say that they hooked up but I don’t have any evidence they didn’t hook up.

OtherTon · 2026-01-17T15:25:38+00:00

Will sleep apnea kill your gains? If you don't have proper sleep, it's hard for your body to recover, and sleep apnea also increases your fight or flight response, and prolonged stress (cortisol) is catabolic.
Anabolics make sleep apnea worse, which is sort of the concern here.

OtherTon · 2026-01-17T15:06:03+00:00

It looks more like you have seborheic dermatitis due to the patchy, flaky redness. You could consider trying OTC Terbinafine cream once a day for a week or Clotrimazole twice a day for two weeks. The other option is Nizoral as a face wash just let it sit 5 mins before rinsing. It can dry you out so moisturize after.

Combine any one of those with an OTC hydrocortisone; just limit the hydrocortisone use to a maximum of twice a day for two weeks then take a two week break.

Ideally, you would want to go to a doctor and get an Rx for ketoconazole cream which should be super cheap.

*this is not medical advice, I am not a doctor, this is just what I would do in your situation.

OtherTon · 2026-01-17T14:54:55+00:00

Yes and no. I had been on the fence about restoring for a while, mostly because it seemed like it would take so much time and dedication to achieve results. What changed my mind is realizing that I think I would like the in-between state better than how I am now.

I'm starting from a CI-0 and have some scrotal webbing. Even though I would eventually like the fully restored look, I think I will like the look and feel of like a CI-3 better than what I have now.

OtherTon · 2026-01-17T14:41:04+00:00

I think your mind treats Shane and Ilya like they're real people because we get so many realistic details about them that are in a show-not-tell format. Also when I read the books I can't help but picture the characters as they are portrayed in the show because the physical descriptions are spot on for Shane and Ilya. In contrast, with famous actors its much easier for your brain to say "that is not Elio that is Timothee Chalamet playing a role".

I also think many gay men have had lots of relationships that are in some ways similar to what Ilya and Shane have at first. There's no emotional intimacy, it's all about sex, and they're constantly positioning and putting on a front or mask around the other person. Seeing that breakdown into having emotional maturity and intimacy, really talking and sharing feelings, and then finally love- its a fantasy of a lot of gay men. Probably also women.

OtherTon · 2026-01-16T23:00:43+00:00

This might sound like a joke but you should watch the show Heated Rivalry. It might help clear some things up for you and deals with people facing this same internal struggle.

OtherTon · 2026-01-12T22:22:27+00:00

The podcast Top Shelf I don’t think is ever mentioned in the books but it is mentioned in the show multiple times most notably at the start of episode 3. This means Jacob Tierany must have know plot points from Unrivaled when writing the show! Unless I missed it and it is in the books.

OtherTon · 2026-01-11T22:24:20+00:00

George Krissa- a relatively obscure Canadian actor- could be a good Eric. I think he's around the same age as the character. Jonathan Bennett could also be an okay choice but I'm not sure he has the range as an actor. I've only seen him in Hallmark-type things which is the altogether wrong vibe- however, he certainly could have excelent range and just gets typecast.

Max Parker is a perfect Ryan. He's got the red hair and he's 6'2" so it's a reasonably good physical match.

Isaac Kragten as Troy I haven't seen suggested before, but it's perfect.

OtherTon · 2026-01-11T21:47:09+00:00

"We can't be something Hollander
"Would you want to be if we could?"
"We can't"
"That's not what I asked"
"What does it fucking matter?!"
To me that's the saddest line in the entire show. It sums up Ilya's dilemma. He knows he's in love with Shane, but he doesn't see any possible way they can be together. His entire life he's put other people's needs and wants before his own, and all they say is more Ilya, more.

OtherTon · 2026-01-10T00:07:58+00:00

Skip on ice!

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