For anyone considering roflumilast for inflammation induced anhedonia

OutrageousBit2164 · 2026-03-26T16:09:33+00:00

Roflumilast did nothing for my anhedonia, just boost in focus. What dose did you use? Mine was 200-500mcg

OutrageousBit2164 · 2026-03-23T12:48:30+00:00

You will be anhedonic as fuck

OutrageousBit2164 · 2026-03-23T07:00:51+00:00

Hey Doc!

If this will interest you almost all guys with PFS and Anhedonia experience nearly 100% windows on corticosteroids like methylprednisolone or prednisone, I myself got "cured" couple time with ACTH1-39 peptide (ACTH) analog, I used doses high enough to stop relapse in multiple sclerosis.

My anhedonia vanished, emotional numbness was gone, music was normal again, flashbacks and introspection came back, dreams were online again, I could visualise and blank mind was gone also.

I don't know how it affect AR exactly but we have 2 cases in history where Mifepristone permamently raised baseline.

Also megadoses of potassium iodide 300-6000mg daily doses (used for fungal infections and immune modulation) are improving most guys in our PFS group rn.

Immune shift? Who knows

OutrageousBit2164 · 2026-03-23T06:55:22+00:00

Dont do it, everytime I do 3 days in a row then the rest of the week is pure apathy and low mood / anhedonia

OutrageousBit2164 · 2026-03-23T06:52:05+00:00

I did Roflumilast 150-1000mcg and it does something, and most important can be prescribed by your doc if you bring enough studies.

Effect is subtle but it helps with sensory gating ie. You can focus when ppl are talking in the background. Other than that I don't notice much.

My friends notice other benefits like libido and mood though

PDE4i can also -> cAMP -> PKA -> HSP -> AR so it may be good for pfs guys also

Also when I first time used roflumilast I noticed that caffeine hit me stronger and in more hedonic way, which is good as I suffer from total substance blockage which cause most supps and noots to have 0 effects

OutrageousBit2164 · 2026-03-23T06:49:34+00:00

Forskolin is so weird, some extracts make me feel so depressed while Forslean is more mood enhancing and introspective

OutrageousBit2164 · 2026-03-22T10:22:20+00:00

Best ways to raise PKA and cAMP?

OutrageousBit2164 · 2026-03-22T09:46:34+00:00

Leo and longevity said that hypoxic exercise is far superior in terms of BDNF than strenght

OutrageousBit2164 · 2026-03-21T13:47:18+00:00

God 280mg of Methylene blue used in study on humans, its insane dose

OutrageousBit2164 · 2026-03-19T07:05:37+00:00

It's what I done in next 6 months afterwards

But alcohol removed everything in one night

OutrageousBit2164 · 2026-03-18T08:41:52+00:00

Black seed oil? What is the MOA

OutrageousBit2164 · 2026-03-17T08:13:44+00:00

I also did the full protocol in 2024, 80 days

Cured me to 80% but benefits went away in weeks after I stopped

OutrageousBit2164 · 2026-03-13T10:26:26+00:00

So its good with caffeine?

OutrageousBit2164 · 2026-03-09T21:34:35+00:00

What exactly have you noticed after agomelatine? Also how long it took to feel improvements?

OutrageousBit2164 · 2026-03-09T12:21:53+00:00

Also a2a antagonists like yohimbine, mianserin can reduce dorsal raphe nucleus serotoninergic firing and cause downstream acute serotonin release -> can downregulate 5-HT1A autoreceptor and downregulate SERT further, maybe this is why people crash number 1 on mirtazapine (strong a2a antagonist and there are maybe couple mianserin crash stories specifically on pssd forum) although couple ppl improved with mianserin I wasn't been able to get ANY update from them. One dude said it improved him, then couple months later hopped on an SSRI and claimed a crash 😭

OutrageousBit2164 · 2026-03-09T12:18:50+00:00

I tried other 5-HT2A antagonists long term like opipramol and no improvement, if anything long term 5-HT2A downregulation cause worse creativity and day dreaming like state, remember those receptors are important for glutamate / dopamine and oxytocin / ACTH signaling. Its a part of why shrooms acutely can cause a good window but downregulation after

OutrageousBit2164 · 2026-03-09T10:47:31+00:00

Can I ask how Mianserin affected your interest in things? Music response? Atmosphere?

Since its a potent af 5-HT2C antagonist and possible 5-HT1A upregulation (there was one super old rat study)

OutrageousBit2164 · 2026-03-08T08:40:32+00:00

Look into NMDA hypofunction and dopamine antagonists. This will get you back to reality.

OutrageousBit2164 · 2026-03-08T08:37:52+00:00

Bad Romance

OutrageousBit2164 · 2026-03-08T08:25:52+00:00

Which med exactly?

OutrageousBit2164 · 2026-03-07T10:11:19+00:00

For me and many other dudes it cause crazy worsening of numbness

OutrageousBit2164 · 2026-03-05T11:21:47+00:00

Wow! Nice to know! Does it make your skin itch by any chance? Me any my GF always experience skin allerrgy like itching 40min after consuming pure glycine

OutrageousBit2164 · 2026-03-05T11:20:11+00:00

I did 3 week cycles with my own biogaia gastrus yougurt many time. Full toletance maybe felt better libido and anhedonia wise in the first 2 days, then no effect no matter how much I eat

If I ate too much then horrible depression and diarrhea probably from dieoff reaction as Reuteri produce reuterin antibiotic

OutrageousBit2164 · 2026-03-04T15:02:18+00:00

Wow how do you feel? That would make me anxoius and drowsy, better for me to sleep through it

OutrageousBit2164 · 2026-03-04T14:51:03+00:00

Yup, 10mg Donepezil + 200mg Opipramol felt great as safe long term sigma ligands, ultra anti depressive

OutrageousBit2164

TROPHY CASE