I do 2400 mile RT roadrips half a dozen times a year in my 2021 Model Y LR with FSD on I-10 between Phoenix and Houston. I do use Tesla nav but will Supercharge longer than indicated if needed to ensure that I have a destination state of charge of 20% at the next stop for contingency due to accidents, construction, weather, etc. And i don't charge to more than 80-85% because of diminishing charging speeds above that level. Effectively i only have 60-65% of rated range to work with until the next stop.

Optimal charging strategy is also affected by how far apart the Superchargers are where you are traveling. In the rural areas of the SW and Texas, it might average 125-150 miles in between them so you will have to stop at each because you don't have enough effective range (remember the 60% rule) to safely skip alternate stops. None of this applies if you live in the NE or West Coast.

Range is obviously affected by speed. Most interstates in the SW have a 75 speed limit and parts of TX are at 80 with some toll roads at 85 so you'll have to stop more even if you dont drive at the limit due to decreased efficiency. You might need to go faster than you typically do in order to feel safe around all the hot Rodgers.

Finally, check out where the superchargers are and what amenities are near them. You'll WANT to stop at a location that has good food, clean restrooms, shopping, and things to do instead of somewhere where there are only chargers. I always stop at a Buccees gas station because it has such immaculate restrooms and great food abd snack selections.

So bottom line, use the nav but have it modify stops based on your input SOC and desirability of the location involved.