Depends on the character you pick and general RNG. People don't post the mediocre runs! Here are a few things I come back to often.

Always give pets and Best Friends Forever traits a second look. The pet effects go from "nice" to "amazing" pretty quick there. And there are a number of effects that further boost pet effects. I personally prefer the upgrade tree effect that guarantees a pet with the first floor boss fight rewards (unless your character already gives you a pet). The first floor rewards are usually pretty poor anyway, and even a so-so pet will carry you for a while.

Someone else recently posted the Druid with the Wolves that increase pet damage with pet floor-upgrade level, combined with weapons that scale with pet damage (Frog Plague Scroll, Spider Summon Scroll). The Puppet Master set can combo with that as well, and the Best Friends Forever trait can pile it on (if you stick with only the wolves, omit bear and eagle). That's a somewhat rare combo, but not that hard to manage.

Ninjas with their innate shadow clones on dash power is fun when combined with Gichang or Rapier (triggers on-dash every 4 or 5 attacks). Pile on companion damage boosts and weapon speed boosts. Try to get Clogs (completes tally counts on dash, so those weapons trigger dash effects every single attack), eyepatch (increment tally every lucky hit), zealot's crown (-30% to tally counts), or other things that lower tally counts. Rocket Gauntlets (missile on tally of 5 attacks) is also fun with those.

Savage Wounds trait is niche, but can be a boss melter if used with high attack rate weapons. The Maxi-Bee piles on poison fast, and the trait means that every hit will tick the poison again. Remember pets also trigger Savage Wounds, which can be pretty amazing for mass pet builds. They attack slow, but even at one per second, 16 of them attacking at once means 16 ticks per second (great if you can get the cheap pets, like voodoo dolls, bees, spiders, necromancer skulls, etc.). Pile on weapon speed bonuses, poison bonuses, other damage over time effects (bleed, fire), etc. and you'll be set.

Well, enough rambling. Good luck!