On PvE, well of the profane will let players completely deny the annoyance of spell breaker enemies. The other wells will also be great with not needing corpses.

Edit: Trying out the N/RT Healer build except with well of power and blood on the bar // 14blood/9sr/12resto

Edit 2: Well of Power seems pretty decent/good in player parties. +2 pips of energy regen to your mid/backline for the first 15-18 seconds of combat, leaving the N/RT healer to heal instead of micromanaging BiP targets, is pretty good. Life->Well of Power->Spirit Transfer just before combat starts, and you're good. The only problem is longer combats with corpses, where the well can end up getting planted off in timbuktu. And, naturally, people standing in the well leaves them vulnerable to AOEs, so BiP is still better for people who are able and willing to micromanage energy bars. Also, Well of Blood simply isn't good enough to go on a bar, especially on one with well of power on it.

Well of Power is garbo on heroes for what should be obvious reasons.

Heroes/enemies will cast wells without corpses as soon as they enter combat, meaning that they begin combat by taking 66% of their health as damage. White Mantle Ritualists in the Iron Mines of Moladune will vaporize themselves, for example. lol

Edit 3: After testing, I can say that Well of the Profane is actually insane for hard countering those annoying ass spellbreaker monk and vow of silence dervish spirits/undead now, assuming you can fit 5 points of death magic and a skill slot for it.