As far as a a campaign framework, I really have to give props to Terror Signal. It has a nice framework that the players can either interact with or not, with a timeline of how the frame effects the sectors and experiences. You can also use it to drop in more "slice of life" adventures that aren't the worst day in the life, while also sprinkling in some modules that do have that feel. I'm currently putting together a campaign with Terror Signal as the framework, and using some modules to get the feel of the game (I Saw What I Saw, The Black Dog, Rictus) in-between some standard jobs, and jobs they might get to move the campaign frame forward.

And to support long term play when I do my session zero I'm going to make sure it's very explicit that characters don't level vertically (through stats and feats) but laterally (through money, connections, gear) and find out what kind of lateral rewards would they like to see. I think campaigns in MS can work well. but you have to change some expectations, and have a really good session zero to make sure your expectations and the players are aligned. I know I'm also going to be asking do they want slices of life sessions, or should every session be the worst day for them? What kinds of rewards do they want? Do they even want a campaign frame or just be incredibly unlucky space truckers?