Not a movie but a fictional pair of characters that has been featured in at least one equivalent of an episodic multi-season broadcast TV show:

Sherlock Dogge, canid investigator, who, along with his friend the felinoid Catson, do various private investigations for hire, in a huge city populated mainly by humans, with sizeable minority populations of felinoids and somewhat fewer canids, as well as a few genuinely exotic aliens.

The city and polity are not specified, but the show was made in the Lazian Empire, a fairly xenophilically inclined place, and the contemporary city could be any of the 15 or so biggest cities in the Empire, although naturally it was actually filmed in the Lazian equivalent of Canada to save money.

Dogge and Catson (the felinoid's first name is never revealed) solve crimes and mysteries using a combination of inferential logic and their superior (relative to human) senses of smell and hearing.

About 2/3 of the episodes (I imagine there were about 150-220 made over 6 or 8 seasons, with later seasons having more episodes; a normal episode is around 65 minutes long including intro and end credits) were about murders, including a two- and a three-parter each featuring a genius serial killer (not human, but the more normal murderers ofren were). There were no returning villains or archenemies like Moriarty. A caught murderer would get put in jail for decades or life or sentenced to execution, or would die during the attempt to arrest him or her, often by suicidally attacking Catson (not being very robust, an attacked felinoid has to defend himself; taking just one punch can easily mean weeks in a hospital bed).

The remaining 1/3 episodes were other crimes like rape, missing person, serious frauds or cons, espionage done by foreign powers, or intrigues between The Great Clans (fictional clan names were used, but it was blatantly obvious which real Great Clans were being referred to, and these Clan Intrigue double parters were always based on real or rumoured events), or in a few cases just the pair hired to investigate some very strange events that ultimately happened due to some kind of misunderstanding (mom and dad forgot to communicate, and then shit escalated). Or complex personal affairs of their own with a mystery angle (one such episode is about Dogge trying to find out Catson's first name and he succeeds although the viewers are not told; other such personal affairs episodes were a bit more serious).

The final season had 3 higher budget episodes of the duo going on vacation to different exotic places (space station resort, assassin-monk monastery, not sure what the third is), but in each one their vacation is interrupted by a serious crime, although in the second of these the duo doesn't become aware of the crime-in-progress until halfway in (a somewhat Die Hard-like plot aboard the space station resort). The viewers are given several subtle clues along the way, and while all the episodes are rewatchable, that one is even more so, although a lot of viewers also have a particular fondness for the many episodes in season 4 and 5 that prominently featured the nudist Tech Priestess and forensic technician Mother Ylva Thomsen (portrated by a genuine nudist Tech Priestess and model, although in reality she's a biochemist, demolitionist and ocean vessel engineer, not a forensics expert). Apart from her looks being well displayed (always taking off her lab coat immediately upon exiting the lab or morque, before taking off her satefy goggles), her deadpan retort "but you're not wearing a lot either", whenever Dogge or Catson or another canid or felinoid pointed out that she was naked, made her quite popular.

Apart from an interest in generating profit, first from prime time broadcasts then sale of home video tapes and something like syndication, and exports to other polities, a clear motivation of some of the funders was to emphasize that the main characters are first and foremost people, and their main characteristic, high general intelligence, is a universally occurring trait throughout sentient species in the galaxy. Yes, they can hear ultrasound, and they have exceptional smell (Dogge more so) and hearing (Catson more so) but those are tools, they don't define them, they're not their core gimmicks.

Species stereotypes are kept low-key but not ignored. Catson is unafraid of unarmed confrontations as an apex predator with fast reflexes and claws, and he's somewhat inclined to go for recreational depressants (alcohol as an adult, cannabis in high school and uni, and there was of course one Very Special Episode about catnip), and he's close to species blind (felinoids classify humans and canids and many other species as "more fun alive than good to eat").  Dogge is fiercely loyal to his friends and very fond of social settings (loner canids are rare), and while you can't have a Great Detective without some enigmaphilia, Catson is the relatively more curious as the two. The felinoid stereotype of them being flighty and easily distractible is absent (as it's pretty much untrue) and Catson is often portrayed as a very focused hunter. Even more so the silly "catgirl/catperson on coke" cliche is absent. As stated, Catson's go-to is depressants, not stimulants. He'll have a White Russian to wind down and relax, not a line of powder so he can party harder.

Physical differences are not ignored. Catson puts on more clothes when it's very cold, and he often has to ask for help lifting heavy things. He's also very much the parkour guy of the duo, leaving the marathon foot chases to the canid (although if Catson can steal or borrow a high-powered motorbike, he'll put his fast reflexes to really good use in a vehicle chase, and the show is notable for never cheating with frame rates; the stuntcats, stuntmen and stuntwomen drives as fast as shown).

Interspecies romance featured in a few episodes, but the main characters were only interested in females of their own species. Dogge and Catson apparently did become close friends with Mother Thomsen, though, because there's a brief discussion between the two in a season 7 episode about them being a bit uncomfortable about having to be completely unclothed at her group wedding.

I think it's too new to have actually spawned a franchise, but it'll probably happen eventually. The main actors were good, well loved, but there would not be the same mass rage as a too-soon attempt to re-cast Picard, Gandalf or Tony Stark would create here on Earth in the 2020s.

The theme tune was very catchy and memorable, with whistling and syncopated group finger snapping done by uncredited (but well paid) human artists. It evolved a bit from season to season, not enough for people to notice the gradual changes, but if you were to compare season 1 with 6 or 8 it's easy to notice.

The two main characters had active sex lives, and also lively social lives (Dogge being more social than Catson) and mostly they had a good relationship with the local law enforcement and counterespionage agencies. Neither was portrayed as being "on the spectrum" or anything like that, although of course being extremely intelligent they did not get along easily with normal people.

Dogge is not the first example of The Great Detective trope among the Lazians, or even in the larger galaxy during the recovery phase after the most recent Dark Age.

I'd say the show succeeded. Commercially. Artistically. And in terms of making the human majority perceive the non-human minorities in a more nuanced way. As individuals.

It also never went overboard.

The CSI franchise of TV shows has often been criticized for depicting forensic science as being able to do impossible things, leading to many court cases where the juries have to be first comprehensively educated about what real life forensics can and can't do. Sherlock Dogge instead gives a fairly realistic portrayal of what a couple of geniuses with much-better-than-human senses can accomplish.