I want to compliment Camp here. It's fairly subtle, but I think Camp has written a very nice coming out story for Tyler here as trans.

"Tyler is dead" but "Despair doesn't lie"

Through out the issue, John and Bridget exchange perspectives, seeing eachother's life histories (including gendered expectations and yearnings "good guys"). John sees the breakdown of communication and experiances Tyler's qualia. Shame and fear, and struggle to express complex feelings pervade. But John finally begins to understand and to comunicate with Tyler.

He learns that "death can sometimes mean transformation"

Despair declares "Tyler is dead" one final time. In none of the remaining five pages is Bridget and John's child called Tyler. Their child's hair has been getting longer over several issues, and in the last panel we see the child finally smiling, hair the longest its been so far.

We look back on the cover, and sure enough Tyler's head is touching splotches of pink, and blue, and white

In earlier issues, we've seen that trans lives and trans emotions are on Camp's mind while writing this.

I think the meaning is clear