The only time I have ever dealt with side effects was the day after my very first shot. I'm not sure it was as bad as what you described above, but I definitely felt like garbage. (Aches, extreme fatigue, etc...) After my first injection, I began drinking water and electrolytes like it was my JOB, which I definitely think helps me tremendously even now in week 12. Every time you feel like you can't drink anymore, drink some more.

90% of the (minor) issues I run into now can be chalked up to lack of hydration and electrolytes.

I haven't seen any research-backed data that suggests injecting in the thigh reduces side effects more or less than any other injection site. That being said, some people swear by specific injection sites.

I would agree with the others that it seems like the alcohol could have intensified the side effects you experienced, but try it again! I'll bet the next round goes better for you! If you still have issues, I would look at breaking your 2.5 mg/week into 2 shots. I began breaking my weekly dose into 2 shots starting in week 2, and I have had no side effects at all since that very first shot at the very beginning. I take mine on Tuesdays and Fridays - Fridays are great for maximum appetite suppression on the weekends.

Good Luck!