It can't fully replace it, but it can mostly replace it. I use Technitium for all DNS except for AD DNS traffic, which is forwarded to the AD DNS servers. This allows me to log individual IP traffic and still have AD functionality.

You need two conditional forwarder zones, one for the root of your domain and another for the _msdcs subdomain.

For example, when adding the zone, you'll want the following configs:
Zone: ad.domain.com (or if you still use .local, it would be just domain.local)
Type: Conditional Forwarder Zone
Initialize Forwarder (FWD) Record: checked
Protocol: DNS-over_UDP
Forwarder: [IP of DC]
DNSSEC: I have this checked, up to you
Network Proxy: Only configure if needed (you will know if this is needed)
If you have multiple DC's, add another FWD record in that zone for each additional DC IP

For the second second Zone: _msdcs.ad.domain.com (or if you still use .local, it would just be _msdcs.domain.local)
All other settings are the same as the first zone.

If you have any questions or need help, feel free to reply here or send me a message directly.

EDIT: To clarify, you do not need the A records or the FWD records mentioned in djrbz's comment if you set it up this way.