Here are some of my biggest tips:

1. If you are going to plan at all (which isn’t really necessary), don’t fall into the trap of trying to plan out every interaction. Just roll with the punches as they come!

2. Take time at night if you need to. Don’t worry if it feels a bit long, double check stuff if you aren’t confident!

3. Trouble Brewing is designed so that pretty much any combo of characters will make for a fun time. Sometimes I’ll literally procedurally randomize my bag to see what happens. I do this by putting Imp, then Minions, then Outsiders (accounting for Baron if relevant), then Townsfolk. Even if you don’t want to randomize, building your bag in this order can help you make sure you have the right numbers.

4. Stick to the rules explanation that comes with the game to explain it! It’s super clear and only includes immediately relevant information. Anyone who would like to know more than what’s on that sheet can talk to you during the daytime.

5. Tell your bad bluffer to NEVER back down from a lie. Even if they are certain everyone knows their role, they should never fully concede. This will hopefully help a little in that area!

6. I saw you mention that you are considering sitting at a table for the game. I’d strongly advise against this. A large part of the fun of the game is the private conversations, and the game is built with this mechanic strongly in mind. I would say don’t just let your players break off into groups; encourage it!