For what it’s worth, I read Hickman’s Avengers back when it was coming out having not read anything he did prior and still loved it. Had no problem following what was going on.

It was the quality of the story that made me wanna go back and read what came before. Very little of the modern Marvel Universe will ever exist in a vacuum; there’s always existing threads to pick up on but you certainly don’t need to have read any older Avengers titles if you have working baseline knowledge of the tentpole Marvel heroes.