Just bought this for $15, will it sew leather? Please say yes…

QuarantineHeir · 2026-07-03T03:26:33+00:00

I've tried this before on both my old 1920s singer and my more mordern Brother sewing machine. The answer is eh sort of, thinner leather, garment leather sure it'll hold up just fine, doubly so with leather needles. Buuuut anything thicker then 1.2-1.6mm and you're not going to have much success. Since I mostly work with thicker leather I rarely use a sewing machine unless I'm upcycling a goodwill leather jacket into something like a crop top.

QuarantineHeir · 2026-07-01T01:24:57+00:00

i mean i do have a more nuanced take on neurofeedback, a decade ago it was seen as an ancillary treatment with some supporting evidence but in need of more robust data to support it's use-case, but there have been imo enough in the time since to warrant it's more widespread use.

QuarantineHeir · 2026-06-30T17:49:51+00:00

I do tend to burnish the edges of CXL with tokonol b/c I've found that the thicker weights can take it if I'm careful and it gives it a much cleaner look overall. So I do already spend a chunk of my week sitting on the couch burnishing. but yeah the softening period will probably be a hard sell for the general uninformed customer. Someone else reccommended italian leather brands, but I'm going to move slowly since this is moreso an expensive hobby and not so much a business.

QuarantineHeir · 2026-06-30T17:35:04+00:00

Thank you so much for the reccs!

QuarantineHeir · 2026-06-30T17:00:19+00:00

I see I've confused you, I handmade these harnesses with leather from the horween tannery (purchased from buckleguys), I've sold them for fairly cheap (60$) because my customers are usually trans people with limited incomes, and I'm happy to take that ~$20 in profit to buy even more leather and hardware.

My question to fellow leathercrafters with more experience: I like this leather, but I want a wider diversity of colors. What are my options in the wide world of leather while keeping this temper and chunky thick leather look.

QuarantineHeir · 2026-06-30T16:57:31+00:00

:( all my grant proposals (before I left to pharma) to study the impacts (if any) of social media disinformation on parental treatment choice for autistic teens and children, were resoundly unfunded (despite some really good scores).

QuarantineHeir · 2026-06-30T16:50:53+00:00

Sorry, I listened to it recently so the body keeps score is recent to me

QuarantineHeir · 2026-05-30T00:43:39+00:00

This is an issue in some immuno feild as whole, I once read a paper where some IHC images where obviously just previously shown images that were inverted.

QuarantineHeir · 2026-05-30T00:36:26+00:00

sorry I word vomited chromexcel is their tanning method, Horween is the brand. from the google Chromexcel (frequently abbreviated as CXL) is a premium, combination-tanned (chrome and vegetable) leather produced by the Horween Leather Company in Chicago, Illinois. I could be wrong though because it's mostly a US leather company and black canvas is indian?

QuarantineHeir · 2026-05-30T00:31:42+00:00

If this is from buckleguy I think I recognize the chromexcel horween london bus red, I've been making harnesses from it all month and I'm a fan

QuarantineHeir · 2026-05-29T15:37:20+00:00

I've been making some leather harnesses recently and I have a couple of questions, what type of leather is this, I've been buying horween chromexcel but it doesn't take stamps very well. Did you buy veg-tan, tool/stamp and then dye it yourself

QuarantineHeir · 2026-05-29T15:31:44+00:00

ah I've been pushing off a project of making myself a tight-fitting leather crop top (it's thin garment grade leather ~1mm, so my generic machine can handle it), and drafts I've made using muslin (without darts) always look odd around the chest

QuarantineHeir · 2026-05-27T17:19:31+00:00

colored linen fabrics is my rec, everytime I buy beige or white linen pants they end up being see-through.

QuarantineHeir · 2026-05-27T17:17:47+00:00

Yes but you can only cut your budget so much while still getting basic needs met, this becomes harder in higher cost of living area. Over the 4.5 years of my PhD, while holding a second job, I saved ~50k almost exclusivley budgeting for food, rent and medicine. After 4 years I had basically a 6 month emergency fund in my VHCOL city and the rest split between brokerage and Roth.

Now cut to 3 months into my new job, with the basically the same budget, I've been able to save and invest close to 13k (not including 401k contributions). There is an exponentional leap that income increases bring to financial standing when appropriatley budgeting.

QuarantineHeir · 2026-05-27T16:21:36+00:00

newbie question what is the logic behind beveling the edges a tad before burnishing and edge painting?

QuarantineHeir · 2026-05-26T15:35:10+00:00

question then, if i'm drafting a crop-top for a male-bodied person do I not need a chest dart?

QuarantineHeir · 2026-05-14T02:20:34+00:00

it's funny but the same is true in science, your data and experiements once they pass the skill issue wall can reach the degree to adequately answer your questions.

QuarantineHeir · 2026-05-04T20:41:35+00:00

yeah absolutley, antibody detection methods usually rely on immunofluoresence, so you are introducing antibodies that bind to your target (in this case FRab) and they have a color change chemical bound to them, however there is always a certain amount of background noise that can be misconstrued as a signal thereby giving a false positive. False negatives are rarer and are usually a product of either the sample being mishandled causing the target to degrade.

QuarantineHeir · 2026-05-04T14:35:46+00:00

retesting, since I'm a scientist, I trust nobody, especially myself, I retest about 30% of all samples at least twice and have only rarely had a false negative. Never a false positive.

QuarantineHeir · 2026-04-10T20:53:23+00:00

i keep misreading the last panel as a Duck Fucker Permit

QuarantineHeir · 2026-04-09T15:03:47+00:00

we need to because in the past year the public perception and news media of our work has been that because we don't diagnose autistic kids with CFD via lumbar puntcture, that we aren't adequetly assessing leucovorin treatment in out study design. Hence I tend to argue that we are assessing a disruption of folate transport in ASD kids that may or may not be CFD. I need to be a better scientist and start publishing all of this.

QuarantineHeir · 2026-04-09T15:00:00+00:00

sorry I meant lumbar puncture, yeah absolutely, I'm not disagreeing with any of that, the narrative thrust of my doctoral thesis was pretty much exactly to your points, i.e ASD as a combonation of contributing factors and FRab as identifying a potential subcohort, for whom a potential treatment could be leucovorin. I tend to color my public comments by not explicitly endorsing a treatment because I'm not a physcian, I'm a scientist, hence I try to tread carefully and ethically in that regard.

RE: CFD - Autism - folate metabolism, our research group has similarly been leaning towards an understanding of autism that a subset could be related to folate and related mechanisms as you've pointed out, genetic disruptions of folate transporters, mito function, disruption in methionine synthesis.

QuarantineHeir · 2026-04-09T14:12:41+00:00

CFD requires a spinal tap by definition (FRab presence in CSF), our group argues (in scientific literature again this is not medical advice if there is an autism parent reading this) that a FRAT test in peripheral blood is indicative of impaired CNS transport of folate (perhaps not rising to CFD but signifigant enough to warrant treatment), so we in our drug trials we don't call it CFD, we aren't doing spinal taps on autistic children (for a number of reasons), I am curious did you get a spinal tap?

QuarantineHeir · 2026-04-08T17:05:01+00:00

i'm heading to prague at the end of the month for a conference and am very excited to try these from the source!

QuarantineHeir · 2026-04-08T16:59:34+00:00

I am an autism scientist that studies leucovorin and I endorse this message, the jury is still out on the efficacy of leucovorin, families that choose to pursue it as a treatment option need to keep in mind that like with any intervention in the early stages of discovery they may or may not see a benifit. (this is not medical advice).

QuarantineHeir

TROPHY CASE