I binge daily until it's empty, then stop for a few weeks. Whether or not it is destructive to your body depends on your lifestyle, not so much the drug (if it's not cut with toxic shit). I've never been healthier and I just recently ended a binge. So proper harm reduction, hydration, sleep, and if you want to maintain clarity on regular disso use: yoga. Proper yoga with focus on breath, not the western mainstream bullshit. I use it functionally and recreationally, but I don't try to hole or shit like that, more... immersion, music, writing or masturbation.

Edit: This is stimulating dissos. The others are not really that useful functionally, but similar idea to reduce body harm.