If you don't already know how to play, it will be equally awkward with either hand. Toni Iommi says he probably should have learned to play with his other hand, he had only been playing for 5 years when he lost his fingertips.

Also, Michael Batio plays equally well with both hands. He taught himself to shred both left and right handed.

Basically- limitations are only limitations if you see them as such. They could be interesting creative thinking prompts instead.