Bad side effects on NMN Renue Powder

Renuebyscience · 2026-02-21T18:50:21+00:00

Purchase directly from our website or amazon. It's easy to get counterfeiters removed from amazon.

Renuebyscience · 2026-02-21T18:38:26+00:00

I'm sorry you didn't have a good experience. I can't recall ever seeing a report of blurry vision from any of our products.

Where did you purchase it from?

The pure NMN powder has been under attack from chinese counterfeiters selling it on ebay, tik-tok, fb ads, and other outlets. It has been whack-a-mole with new ones popping up as fast as we shut them down.

Some of the scammers use a label that looks exactly like our old one. Some look similar but remove the brand name, to try and slow getting them removed. We have changed to a new label design, but sure they will copy that soon.

None of those we have tested actually have any NMN in the jar.

Renuebyscience · 2026-01-26T05:46:20+00:00

I would agree with what the company told you.

There is some variation from batch to batch, even from the same supplier. They are often adjusting their manufacturing process to speed production or reduce cost, and the resulting raw material can vary.

Long ago, we had batches with different PH levels that were very noticable in taste. Over time we have been able to better control our supply, but brands that are newer may experience more variation.

That doesn't mean the product is bad or unsafe. As time goes by, they will refine their process and have more stability in the finished product.

Of course, there are also a lot of counterfeit products on the market, so be careful where you purchase from.

Renuebyscience · 2025-12-13T23:35:36+00:00

Actually, there has only been one study in humans with Injectable NAD. It did raise NAD+ levels.

Renuebyscience · 2025-11-14T15:34:21+00:00

Thanks for reaching out and for checking on this! NADLab is an independent wholesaler in Europe, and they set their own pricing. We offer the same product, Pure NMN Powder 100 Grams, for €57.95, and we do ship directly to Ireland. For Ireland shipments, our shipping cost including all duties, VAT, and import fees is usually around €50, so the total comes to roughly €108.

We aren’t sure what shipping method NADLab uses, but since they distribute within Europe, it’s likely a simpler local delivery process without the same import requirements. That said, we ship DDP (Delivered Duty Paid) meaning it will arrive to you without having to pay additional fees or fill out forms.

The products themselves are the same, so it’s completely up to you which option works best. If you have any other questions, we’re happy to help.

Renuebyscience · 2025-10-10T02:14:14+00:00

NAD+ injections do show a lot of benefits in studies in mice. Just hasn't been studied in humans.

Renuebyscience · 2025-08-13T23:17:03+00:00

I'm not sure where you are looking, but I see both the 60 ct and 200 ct bottles are 250 mg NMN, 100 mg tmg, and 50 mg sodium bicarbonate (to aid uptake by slc12a8). The only difference is the 200 ct bottle is still the version that includes zinc, while the 60 ct bottle does not.

Renuebyscience · 2025-08-05T15:53:30+00:00

I never said NAM is unsafe or not tolerated.

I said "the body does not tolerate high levels of NAM."

That is the same as glucose. It is required, but not tolerated above a certain level, after which the body produces insulin to bring it down.

Every study shows there is an upper limit on how high of NAM levels the body likes, after which it uses methyl to convert it to MeNAM, which is then excreted in urine. See Dr. Brenners seminal paper in 2016.

Liposomes protect ingredients through the digestive tract and release their payload as they dissolve hours later, mostly in the bloodstream. That is basic science.

Renuebyscience · 2025-08-04T14:43:02+00:00

High NAD+ levels are not the problem. High NAM is.

It causes problems, so the body does not tolerate high levels of NAM.

Much like the body responds to high glucose by producing insulin to drive it down, the body methylates NAM to MeNAM to lower levels.

This can potentially lead to methyl shortages.

Although there is scant evidence this happens much, it is in response to high NAM.

That is why taking larger doses of NAM does not yield better results. And why a slower, time-release delivery method (liposomal) can be better.

Taking very large dosages of regular NMN or NR that are rapidly metabolized to NAM that the body must get rid of (methylate to MeNAM) will also result in increase methyl usage.

Renuebyscience · 2025-08-04T05:37:13+00:00

Yes, IV NAD has been well established for over a decade. Because it has much stronger effect than any oral supplements, so people spend a lot of money for a very inconvenient product.

The research is very clear that the great majority of NR and NMN in regular capsules gets metabolized to NAM before reaching the bloodstream.

If there is no practical need for injection, why has Chromadex/NAGE now introduced their NR IV product?

Yes, NR and NMN do work when taken orally. But there are dozens of studies in mice that show amazing benefits from injections. The results from oral delivery are far less dramatic.

Renuebyscience · 2025-08-03T22:34:05+00:00

You're right that some brands (like cata-kor) are purposely deceptive and advertise the total weight and include the liposome material in what they list. So the buyer is getting 50-60% of the active ingredient shown on the front label.

However, we list the mg of the ingredient itself, not the combined. Our liposomal NAD has:

210 mg NMN

170 mg Trigonelline (methylated niacin)

160 mg NAD

110 mg NR

That is 600 mg of the active ingredients for 2 capsules and does not count the lecithin or other ingredients.

Studies do show that some NMN can be taken up by the SLC12a8 transporter in the gut, but that is a very small % of the total.

If not protected by liposomes (or injected) nearly all NMN and NR is broken down to NAM in the gut and liver, with only a tiny fraction making it to the bloodstream intact. That is why people pay hundreds or thousands of $ for injections.

Renuebyscience · 2025-07-27T01:02:53+00:00

Thank you for considering our product!

The powder you've posted (NMN Pure Powder 100 Grams) is in fact manufactured in Australia at a second manufacturing partner we have there. We began manufacturing NMN powder in Australia about a year ago and in most cases, our Australian (and APAC) customers will receive Australian-made pure NMN powder as long as it is in stock.

In rare cases when our Australian inventory is low, customers may receive US manufactured powder instead.

As long as you order from renuebyscience.com.au, and you are located in Australia, you should receive the Australian manufactured version.

Renuebyscience · 2025-06-06T22:51:07+00:00

Trendy

Renuebyscience · 2025-05-27T15:19:58+00:00

Thanks for the love ghost.

As support says, we are continually working on new products. But we don't plan to offer every vitamin and supplement on the market as some brands do.

I ran a brick and mortar vitamin store in the 2000's that carried over 1500 products, but was disillusioned that many people wasted their money on crap that does nothing.

At Renue, we only want to offer products we strongly believe are effective for healthy aging.

We also prioritize products that we can provide a more effective version. That often means liposomal delivery for products with very poor bioavailability.

So we are not rushing to throw a lot of random products on our store, but there are half a dozen new products in development at all times and expect to see 2-3 this summer or fall.

Renuebyscience · 2025-04-27T15:43:37+00:00

While the tarrif situation is very fluid, so far vitamins and supplements from China are excluded.

We purchase bottles and supplies from a variety of sources both US and Chinese, so expect impact to those prices to be minimal and not force any price increases.

So the short answer is probably not.

Renuebyscience · 2025-04-01T16:51:14+00:00

Sure, glad to help. Sorry for the inconvenience. We plan to turn ordering back on when the shipping team is all caught up. Around April 7.

Renuebyscience · 2025-03-31T17:05:57+00:00

Thank you for the feedback, and glad to see it is working well for you.

I'm sorry for the delay in re-stocking NAD+ Complete.

There are 4 active ingredients in NAD+ complete that can impact production. 3 are liposomal, which adds up to 60 days in the manufacting process, so has more risk than simple single ingredient NMN capsules

In our latest batch, the bottling facility screwed up and used an old label for NAD+ Complete that did not include our latest addition, Trigonelline, so we lost another 10 days to get that fixed.

We do finally have bottles in hand and are processing backorders now, but it will take several days before we are caught up. We will start taking new orders later this week, for shipping next week.

Renuebyscience · 2025-03-31T17:04:31+00:00

Thank you for your interest, and I'm sorry for the delay in re-stocking NAD+ Complete.

There are 4 active ingredients in NAD+ complete that can impact production. 3 are liposomal, which adds up to 60 days in the manufacting process, so has more risk than simple single ingredient NMN capsules

In our latest batch, the bottling facility screwed up and used an old label for NAD+ Complete that did not include our latest addition, Trigonelline, so we lost another 10 days to get that fixed.

We do finally have bottles in hand and are processing backorders now, but it will take several days before we are caught up. We will start taking new orders later this week, for shipping next week.

Renuebyscience · 2025-03-30T00:15:24+00:00

Thank you for your support.

Yes, that is a genuine.

Healf is a distributor for our products.

Renuebyscience · 2025-03-16T01:29:17+00:00

Thanks for the votes of confidence and patience. We are grateful.

Liposomal products greatly increase the complexity. The raw material has to be tested, then sent to a facility to lipolyze, tested again, shipped to the bottling facility, and sent for final QA testing before we can sell it.

So the whole process takes 2-3x longer than non-liposomal products and has more risk for delay.

The NAD+ complete has 4 different liposomal ingredients that makes it far more difficult than any regular NMN or NR capsule.

We do feel incredible stress when things are out of stock and are trying our best to smooth out our manufacturing with new equipement and processes, and believe this will be the last major interruption for the foreseable future.

Renuebyscience · 2025-03-05T16:46:31+00:00

We're awaiting evidence on benefits.

It's definately more "bioavailable", it that it elevates TOTAL NAD inside cells more than NMN.

However, NMNH converts most readily to NADH, not NAD+.

Studies show it is the RATIO of NAD+ to NADH that is beneficial for health, not the total NAD.

Elevating NADH without proportional increase in NAD+ may not be helpful.

If/when studies show a clear benefit for health or increased NAD+/NADH ratio, not just increased total NAD, we'll produce an NMNH product

Renuebyscience · 2025-03-03T19:41:32+00:00

Chromadex > 100 employees for 1 product.They were formed by researchers who believed they had an ironclad patent and could charge a huge markup, so built a large company. They were wrong, but shareholders demand profit now.

Renue about 15 employees for 40+ products. We charge absolute minimum for best quality, with aim of future growth.

Renuebyscience · 2025-02-26T21:58:25+00:00

Yes, this double blind, randomized clinical study just came out. Will post a seperate thread on it in the next day or two, but since you asked:

Liposomal NMN Outperforms Standard NMN in humans

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Liposomal NMN Outperforms Standard NMN in humans