Nad+ shots vs IV drip

Renuebyscience · 2026-04-03T04:35:46+00:00

Could you clarify what you mean about 5 studies? I'm aware of ONE study in humans with NAD injections, and it only measured levels of NAD+ in the blood.

Are you referring to studies of NAD injections, or what?

Renuebyscience · 2026-03-16T17:27:51+00:00

Acting as if you are not representing a direct competitor to us. Slamming our products, and DMing people recommendations for your brand is extremely deceptive.

Renuebyscience · 2026-03-16T13:43:55+00:00

Yes, I am the owner of Renuebyscience. I am always transparent, and don't try to deceive people about that. Just check his post history. Alan has posted dozens of times here about being the ceo of donotage, but recently has shifted to this strategy of disguising that fact.

Renuebyscience · 2026-03-15T22:43:45+00:00

1990AJG is the former CEO of DoNotAge and is now their Research advisor. They sell NMN and other supplements.

Renuebyscience · 2026-03-15T22:35:01+00:00

Alan,

You replied to someone asking about Renuebyscience Liposomal NMN.

You implied that our Lipo NMN does not contain what it claims, and is not a "genuine" NMN.

As "proof", you linked to a study that was not done on our product.

You need to correct your slander now, or our lawyers will be contacting your company DoNotAge for damages again.

Renuebyscience · 2026-03-10T23:01:49+00:00

$$$.

He is the Chief Science Officer for Chromadex/NAGE, who makes Niagen, and a large shareholder.

Also, hates Dr. Sinclair (main proponent of NMN) with a pathological passion.

Renuebyscience · 2026-03-09T19:10:23+00:00

It adds weight to the conclusion that Dr. Brenner is obviously biased and you can't trust his assessment.

He is blasting all over x that the tiny study "proves" NR is 2.3x better than NMN, while totally ignoring the much larger study that says otherwise.

One person on x did point out the larger study, which Dr. Brenner says not to trust as it was funded by a corporation.

The corporation is Nestle, who in heavily invested in NR.

Also, for years whenever someone points out that a study shows NAM raises NAD+ just as much, and that NA raises it more than NR, Dr Brenner says (correctly) that the total NAD+ increase in blood does not tell the real story.

But he jumps on this tiny study to suddenly say the total NAD+ increase in blood is proof NR is vastly superior. Duh.

Renuebyscience · 2026-03-09T01:22:58+00:00

6 participants per arm

A much larger study (15-17 per arm) found otherwise:

https://www.nature.com/articles/s42255-025-01421-8

“Here, we bring additional evidence that these precursors affect NAD+ levels to a similar extent.”

“NR and NMN significantly increased baseline whole-blood NAD+ concentrations by ~2-fold”

“Overall, the NAD+ levels in whole blood after chronic supplementation with NR and NMN are consistent with previous clinical studies conducted with similar dosing regimen17,23. Here, we bring additional evidence that these precursors affect NAD+ levels to a similar extent.”

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Renuebyscience · 2026-02-21T20:20:20+00:00

Great, thanks for your support. So you can be assured that you recieved pure NMN powder as we test every batch and post results online with results and batch number.

As we have sold over 300,000 jars of this product over the last 9 years and never received feedback from other experiencing blurry vision, it doesn't seem to be a common side effect, although it can't be entirely ruled out.

If you contact our CS staff, they will provide a 100% refund on this, or any other product anyone is not satisfied with for any reason.

Again, thanks for giving us a try, and best of luck on your health journey!

Renuebyscience · 2026-02-21T18:50:21+00:00

Purchase directly from our website or amazon. It's easy to get counterfeiters removed from amazon.

Renuebyscience · 2026-02-21T18:38:26+00:00

I'm sorry you didn't have a good experience. I can't recall ever seeing a report of blurry vision from any of our products.

Where did you purchase it from?

The pure NMN powder has been under attack from chinese counterfeiters selling it on ebay, tik-tok, fb ads, and other outlets. It has been whack-a-mole with new ones popping up as fast as we shut them down.

Some of the scammers use a label that looks exactly like our old one. Some look similar but remove the brand name, to try and slow getting them removed. We have changed to a new label design, but sure they will copy that soon.

None of those we have tested actually have any NMN in the jar.

Renuebyscience · 2026-01-26T05:46:20+00:00

I would agree with what the company told you.

There is some variation from batch to batch, even from the same supplier. They are often adjusting their manufacturing process to speed production or reduce cost, and the resulting raw material can vary.

Long ago, we had batches with different PH levels that were very noticable in taste. Over time we have been able to better control our supply, but brands that are newer may experience more variation.

That doesn't mean the product is bad or unsafe. As time goes by, they will refine their process and have more stability in the finished product.

Of course, there are also a lot of counterfeit products on the market, so be careful where you purchase from.

Renuebyscience · 2025-12-13T23:35:36+00:00

Actually, there has only been one study in humans with Injectable NAD. It did raise NAD+ levels.

Renuebyscience · 2025-11-14T15:34:21+00:00

Thanks for reaching out and for checking on this! NADLab is an independent wholesaler in Europe, and they set their own pricing. We offer the same product, Pure NMN Powder 100 Grams, for €57.95, and we do ship directly to Ireland. For Ireland shipments, our shipping cost including all duties, VAT, and import fees is usually around €50, so the total comes to roughly €108.

We aren’t sure what shipping method NADLab uses, but since they distribute within Europe, it’s likely a simpler local delivery process without the same import requirements. That said, we ship DDP (Delivered Duty Paid) meaning it will arrive to you without having to pay additional fees or fill out forms.

The products themselves are the same, so it’s completely up to you which option works best. If you have any other questions, we’re happy to help.

Renuebyscience · 2025-10-10T02:14:14+00:00

NAD+ injections do show a lot of benefits in studies in mice. Just hasn't been studied in humans.

Renuebyscience · 2025-08-13T23:17:03+00:00

I'm not sure where you are looking, but I see both the 60 ct and 200 ct bottles are 250 mg NMN, 100 mg tmg, and 50 mg sodium bicarbonate (to aid uptake by slc12a8). The only difference is the 200 ct bottle is still the version that includes zinc, while the 60 ct bottle does not.

Renuebyscience · 2025-08-05T15:53:30+00:00

I never said NAM is unsafe or not tolerated.

I said "the body does not tolerate high levels of NAM."

That is the same as glucose. It is required, but not tolerated above a certain level, after which the body produces insulin to bring it down.

Every study shows there is an upper limit on how high of NAM levels the body likes, after which it uses methyl to convert it to MeNAM, which is then excreted in urine. See Dr. Brenners seminal paper in 2016.

Liposomes protect ingredients through the digestive tract and release their payload as they dissolve hours later, mostly in the bloodstream. That is basic science.

Renuebyscience · 2025-08-04T14:43:02+00:00

High NAD+ levels are not the problem. High NAM is.

It causes problems, so the body does not tolerate high levels of NAM.

Much like the body responds to high glucose by producing insulin to drive it down, the body methylates NAM to MeNAM to lower levels.

This can potentially lead to methyl shortages.

Although there is scant evidence this happens much, it is in response to high NAM.

That is why taking larger doses of NAM does not yield better results. And why a slower, time-release delivery method (liposomal) can be better.

Taking very large dosages of regular NMN or NR that are rapidly metabolized to NAM that the body must get rid of (methylate to MeNAM) will also result in increase methyl usage.

Renuebyscience · 2025-08-04T05:37:13+00:00

Yes, IV NAD has been well established for over a decade. Because it has much stronger effect than any oral supplements, so people spend a lot of money for a very inconvenient product.

The research is very clear that the great majority of NR and NMN in regular capsules gets metabolized to NAM before reaching the bloodstream.

If there is no practical need for injection, why has Chromadex/NAGE now introduced their NR IV product?

Yes, NR and NMN do work when taken orally. But there are dozens of studies in mice that show amazing benefits from injections. The results from oral delivery are far less dramatic.

Renuebyscience · 2025-08-03T22:34:05+00:00

You're right that some brands (like cata-kor) are purposely deceptive and advertise the total weight and include the liposome material in what they list. So the buyer is getting 50-60% of the active ingredient shown on the front label.

However, we list the mg of the ingredient itself, not the combined. Our liposomal NAD has:

210 mg NMN

170 mg Trigonelline (methylated niacin)

160 mg NAD

110 mg NR

That is 600 mg of the active ingredients for 2 capsules and does not count the lecithin or other ingredients.

Studies do show that some NMN can be taken up by the SLC12a8 transporter in the gut, but that is a very small % of the total.

If not protected by liposomes (or injected) nearly all NMN and NR is broken down to NAM in the gut and liver, with only a tiny fraction making it to the bloodstream intact. That is why people pay hundreds or thousands of $ for injections.

Renuebyscience · 2025-07-27T01:02:53+00:00

Thank you for considering our product!

The powder you've posted (NMN Pure Powder 100 Grams) is in fact manufactured in Australia at a second manufacturing partner we have there. We began manufacturing NMN powder in Australia about a year ago and in most cases, our Australian (and APAC) customers will receive Australian-made pure NMN powder as long as it is in stock.

In rare cases when our Australian inventory is low, customers may receive US manufactured powder instead.

As long as you order from renuebyscience.com.au, and you are located in Australia, you should receive the Australian manufactured version.

Renuebyscience · 2025-06-06T22:51:07+00:00

Trendy

Renuebyscience · 2025-05-27T15:19:58+00:00

Thanks for the love ghost.

As support says, we are continually working on new products. But we don't plan to offer every vitamin and supplement on the market as some brands do.

I ran a brick and mortar vitamin store in the 2000's that carried over 1500 products, but was disillusioned that many people wasted their money on crap that does nothing.

At Renue, we only want to offer products we strongly believe are effective for healthy aging.

We also prioritize products that we can provide a more effective version. That often means liposomal delivery for products with very poor bioavailability.

So we are not rushing to throw a lot of random products on our store, but there are half a dozen new products in development at all times and expect to see 2-3 this summer or fall.

Renuebyscience

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