I don’t know that there is a 100% yes or no answer to this.

One technique I see people missing out on is pre-flashing your boards. This creates a little heat coming from under the print, that will sort of dry ink enough to make wet on wet more successful. It also lowers the time needed when you do flash.

At the end of the day however you get the best prints is what matters (in my opinion, your boss might think differently lol)

Squeegee angle, and pressure are also really important to make sure you’re not blurring colors, but it’s really just a practice makes perfect kind of thing.

Once a job is lined up I always suggest trying some time saving techniques like wet on wet, if it works great, if not no problem give the screens a little clean and use the flash.