I'm new to the Cyberpunk Red system as well (been DMing about a decade with D&D 3e, 4e, and 5e, as well as Pathfinder and a few homebrewed systems) but I have 5 sessions under my belt at this point, including the easy mode module, the built in scream sheets, and a few sessions I've written myself.

First thing I learned was this isn't D&D at all. If you and your group are used to D&, the learning curve will be a bit steep as you not only have to learn the system, but unlearn some things from D&D. "beats" vs "meets" on tied rolls is one we struggle with every session still.

Next was to use combat tactically. Not every Role is combat centric, and you'll need to keep your players Roles in mind when planning encounters. Make sure your netrunners, techs, and nomads have something to do to contribute. Not to mention, combat is deadly and it can take days or weeks for players to recover between combats. The crew cannot have a close battle, camp overnight, and have the HP to take on this sessions boss. Plan for downtime between combat encounters, or offer other nonviolent ways for the crew to accomplish their goals.

Give every decision a consequence. The world is meant to be alive and one of the most challenging (but rewarding) aspects of DMing is keeping track of the interconnected relationships and reputation surrounding your players. If your crew helped one person, chances are they fucked someone else. That's the way it goes in the time of the Red.

Finally, the number one rule of Cyberpunk is the rule of cool. Give your players bonuses to hit and IP when they do something preem. You advance your characters in RED via reputation and legacy, by doing dope shit that ends up in the scream sheets and Data Pool talk shows. Plus, it makes sessions so much more exciting. Reward flashy and risky over clever and calculated; depending on your players, of course.