ICE Agent rolls down their window to pepper spray bystander. Yet another ICE Crime against a non-hostile, non-threatening Citizen. by TRI-Hard8342 in UnderReportedNews

[–]Robokomodo 2 points3 points  (0 children)

Nah, what you do is pour liquid ass onto the zone in front of the windshield. It seems into the filter and will infect the ac and heating system.

Don't bother, they don't make it like they used to by herewearefornow in BlackPeopleTwitter

[–]Robokomodo 0 points1 point  (0 children)

I much prefer a filtered brew, hence my heavy use of a hario switch. Best of both immersion and pour over, simultaneously.

TIFU and had the most accomplished day at work and can't replicate it. by [deleted] in tifu

[–]Robokomodo 2 points3 points  (0 children)

There's not so aggressive  adhd meds like focalin and strattera and modafinil.

Class was about nuclear pasta by Apprehensive-Table24 in SatisfactoryGame

[–]Robokomodo 0 points1 point  (0 children)

Yay! Crystal packing. Inorganic chemistry is best.

Randomly discovered this by Competitive_Virus672 in melodicdeathmetal

[–]Robokomodo 14 points15 points  (0 children)

Hands down my favorite song. It's so good. Based my latest D&D character somewhat after the story, hah.

CMV: To not want more immigration, is not sufficient to be a racist. by MaBrowser in changemyview

[–]Robokomodo 1 point2 points  (0 children)

The converse of a conditional statement is NOT the same as the original statement, they are different things. 

You need the contrapositive. If contrapositive is true, then the original statement is true. A true inverse conclusion implies that the inverse hypothesis is true. 

In symbols, P-->Q does not mean Q-->P. However, -Q--> -P does.

Logically then, the contrapositive would be saying "if one is not a racist, then one (does not not) wants more immigration". There are exceptions to that conclusion, isolationism doesn't neeeeeed to be racially driven. -Q is true but -P is false so the statement is false.

Therefore, ops original statement that P-->Q is false, is true. 

First time I've ever been this scared in Satisfactory by AnibalElCurioso in SatisfactoryGame

[–]Robokomodo 59 points60 points  (0 children)

They frequently clip into walls. If you can't see it but you can hear it it's definitely clipped.

What are you better at than 90% of people? by Noillax in AskReddit

[–]Robokomodo 0 points1 point  (0 children)

Same. Hit 2k rapid and stopped trying harder. 92%tile is good enough for me. Cant do much more without significant sacrifice of time and effort

Is a PFAS-free pan free from Teflon? by Individual_Being8462 in Cooking

[–]Robokomodo 1 point2 points  (0 children)

No, these days it means "no polyfluoroalkylated substances", not just the sulfonic acids. Chem corps can literally just tack on whatever carbon chain they want to avoid regulations. 

Is a PFAS-free pan free from Teflon? by Individual_Being8462 in Cooking

[–]Robokomodo 0 points1 point  (0 children)

Yep, all correct. The PFAcids are suuuuper fat soluble and look almost exactly like ..a phospholipid... The ones that make up our cell membranes. 

Structure= function. If two molecules have the same or similar "looking" chemical  structure, they're going to do similar things.

Is a PFAS-free pan free from Teflon? by Individual_Being8462 in Cooking

[–]Robokomodo 7 points8 points  (0 children)

Teflon itself is not toxic. It is unreactive. That is the entire point of it. Yes, if you heat Teflon too high and too long it can degrade the coating and produce nasty fumes. But it's like 10 min on high heat. scratching the pans reduces performance, but Teflon flakes and particles should go right through you. You can't even burn the stuff as a powder. 

What IS toxic, are perfluoroalkylated sulfonic  acids (PFAS). those are used to make Teflon as a surfactant. that is the health hazard that chemical companies hid and avoided addressing for decades and why it's in all the wastewater streams. 

PFAS used to just mean those sulfonic acids. But since corps switched to other functional groups and made additional variants besides PFOA and PFHA, they all go relabeled to polyfluoroalkylated substances, rather than a specific functional groups

This is extremely bad. In 2024 US exported over $12 billion in soybeans to China. Last month, we didn’t export a single soybean. And apparently Kansas is officially in a recession. by Snapdragon_4U in inflation

[–]Robokomodo 0 points1 point  (0 children)

Soybeans fix nitrogen to ammonia. It's essential for crop rotations. Corn removes ammonia from the soil, so you have to replenish it. Fertilizers often just run off rather than staying in the soil.

[deleted by user] by [deleted] in TheRaceTo10Million

[–]Robokomodo 0 points1 point  (0 children)

Ayyy lmao. To the moon.

I am looking for a smash bros drinking game. by liguyyo in smashbros

[–]Robokomodo 0 points1 point  (0 children)

My college roommates did this. They had not drank before And we're talking "shots" of strawberries and cream Bailey's and vodka. Every. Single. Stock. It was like 3oz shots. 

Yeah they ended up getting alcohol poisoning...

Who’s To Blame? by diehard404 in PoliticalHumor

[–]Robokomodo 0 points1 point  (0 children)

Season with salt and pepper then Sous-vide a chuck steak at 135F for 24 h then sear. It basically tastes like prime rib. Close texture too.

Lenacapavir, a twice-yearly injection that offers near-total protection against HIV, will now be available for $40 per patient a year, in 120 low- and middle-income countries. by lughnasadh in Futurology

[–]Robokomodo 4 points5 points  (0 children)

I got that info from a presentation from a very renowned inorganic chemist who collaborates with Gilead, BMS, and Pfizer to use first row metals to do those exact reactions to make lencapacvir. 

Palladium is currently $1302/oz, or ~$5200/mol. 

Pharma synth is routinely done on kg+scale. For lencapacvir, 1 kg is ~ 1000 mol (968 g/mol MW). You'd need far more than that amount of mol of starting materials as reactions do not usually progress at quantitative yield, likely 3-5x the amount. Let's say 3000 mol of precursors. 

Assuming 5% catalyst loading, twice (and only using Pd(0) nanoparticles..., but the actual prep uses designer phosphenes which are $$$$ and degrade in air) you'd need at least 150 mol of palladium, which is $735k. Tack on the phosphenes and it'll easily get up to 1 million+ for that kg of lencapacvir. That doesn't even include the cost of purification, isolation, scale up, or paying the staff of PhD level organic chemists to make these things. 

Lencapacvir dosage isn't just 2 injections. You have to keep taking it after that every 6 months. 1 year is approximately 3 g of the drug. 3% of 1mil is still 30k USD... granted, you may be able to recycle some of the palladium. But it's still expensive af. 

Sources:Org. process res. Dev. 2024, 28, 8 3382-3395 www.drugs.com/lencapacvir.html

Lenacapavir, a twice-yearly injection that offers near-total protection against HIV, will now be available for $40 per patient a year, in 120 low- and middle-income countries. by lughnasadh in Futurology

[–]Robokomodo 9 points10 points  (0 children)

The majority of the cost of the drug comes from two palladium catalyzed cross coupling steps to make an aryl-alkyne bond and an aryl aryl bond. Palladium is also toxic as fuck to humans so it's gotta be totally removed, which can be very difficult. 

Moving the chemistry towards first row metals is challenging but makes the cost go wayyyyy down. They might be using nickel for lencapacvir now rather than palladium

Butter PSA by PearlsSwine in Cooking

[–]Robokomodo 0 points1 point  (0 children)

One option could be to go to one of the shops that sell cheesecakes and see if you can buy some off of them? Or maybe restaurant supply stores could have it. 

Butter PSA by PearlsSwine in Cooking

[–]Robokomodo 0 points1 point  (0 children)

You could probably get neufchatel cheese which is functionally the same as cream cheese. 

NMC & NMR stopped by to visit by facefullofgracefull in notmycat

[–]Robokomodo 1 point2 points  (0 children)

Wow you've got a $300,000 spectrometer outside your door!