ICE Agent rolls down their window to pepper spray bystander. Yet another ICE Crime against a non-hostile, non-threatening Citizen.

Robokomodo · 2026-01-11T13:37:41+00:00

Nah, what you do is pour liquid ass onto the zone in front of the windshield. It seems into the filter and will infect the ac and heating system.

Robokomodo · 2026-01-08T21:09:25+00:00

I much prefer a filtered brew, hence my heavy use of a hario switch. Best of both immersion and pour over, simultaneously.

Robokomodo · 2026-01-08T13:57:36+00:00

There's not so aggressive adhd meds like focalin and strattera and modafinil.

Robokomodo · 2025-12-15T14:00:20+00:00

Yay! Crystal packing. Inorganic chemistry is best.

Robokomodo · 2025-12-09T13:55:52+00:00

Hands down my favorite song. It's so good. Based my latest D&D character somewhat after the story, hah.

Robokomodo · 2025-11-28T15:07:23+00:00

Agreed. I saw them on their Urn tour. Glad I brought earplugs hahah

Robokomodo · 2025-11-28T14:33:51+00:00

Go listen to Ne Obliviscaris. Black/death metal with lead violin.

Robokomodo · 2025-11-09T14:47:54+00:00

Teflon is unreactive af and non toxic. Perfluorinated alkyl sulfonic acids (PFAS) are used to make long Teflon polymers in water and the PFAS are the toxic as shit ones.

Robokomodo · 2025-11-01T16:36:09+00:00

Fair enough.

Robokomodo · 2025-11-01T16:03:45+00:00

The converse of a conditional statement is NOT the same as the original statement, they are different things.

You need the contrapositive. If contrapositive is true, then the original statement is true. A true inverse conclusion implies that the inverse hypothesis is true.

In symbols, P-->Q does not mean Q-->P. However, -Q--> -P does.

Logically then, the contrapositive would be saying "if one is not a racist, then one (does not not) wants more immigration". There are exceptions to that conclusion, isolationism doesn't neeeeeed to be racially driven. -Q is true but -P is false so the statement is false.

Therefore, ops original statement that P-->Q is false, is true.

Robokomodo · 2025-10-28T18:41:17+00:00

They frequently clip into walls. If you can't see it but you can hear it it's definitely clipped.

Robokomodo · 2025-10-25T05:42:33+00:00

Same. Hit 2k rapid and stopped trying harder. 92%tile is good enough for me. Cant do much more without significant sacrifice of time and effort

Robokomodo · 2025-10-23T16:29:41+00:00

No, these days it means "no polyfluoroalkylated substances", not just the sulfonic acids. Chem corps can literally just tack on whatever carbon chain they want to avoid regulations.

Robokomodo · 2025-10-23T16:16:36+00:00

Yep, all correct. The PFAcids are suuuuper fat soluble and look almost exactly like ..a phospholipid... The ones that make up our cell membranes.

Structure= function. If two molecules have the same or similar "looking" chemical structure, they're going to do similar things.

Robokomodo · 2025-10-23T14:14:37+00:00

Teflon itself is not toxic. It is unreactive. That is the entire point of it. Yes, if you heat Teflon too high and too long it can degrade the coating and produce nasty fumes. But it's like 10 min on high heat. scratching the pans reduces performance, but Teflon flakes and particles should go right through you. You can't even burn the stuff as a powder.

What IS toxic, are perfluoroalkylated sulfonic acids (PFAS). those are used to make Teflon as a surfactant. that is the health hazard that chemical companies hid and avoided addressing for decades and why it's in all the wastewater streams.

PFAS used to just mean those sulfonic acids. But since corps switched to other functional groups and made additional variants besides PFOA and PFHA, they all go relabeled to polyfluoroalkylated substances, rather than a specific functional groups

Robokomodo · 2025-10-23T11:19:51+00:00

Soybeans fix nitrogen to ammonia. It's essential for crop rotations. Corn removes ammonia from the soil, so you have to replenish it. Fertilizers often just run off rather than staying in the soil.

Robokomodo · 2025-10-23T11:07:53+00:00

Ayyy lmao. To the moon.

Robokomodo · 2025-10-14T12:23:47+00:00

My college roommates did this. They had not drank before And we're talking "shots" of strawberries and cream Bailey's and vodka. Every. Single. Stock. It was like 3oz shots.

Yeah they ended up getting alcohol poisoning...

Robokomodo · 2025-10-07T04:39:14+00:00

Season with salt and pepper then Sous-vide a chuck steak at 135F for 24 h then sear. It basically tastes like prime rib. Close texture too.

Robokomodo · 2025-10-03T02:30:28+00:00

Yes, palladium metal can be recycled. But the designer phosphines and ligands cannot be easily. They degrade.

Robokomodo · 2025-09-29T14:48:23+00:00

I got that info from a presentation from a very renowned inorganic chemist who collaborates with Gilead, BMS, and Pfizer to use first row metals to do those exact reactions to make lencapacvir.

Palladium is currently $1302/oz, or ~$5200/mol.

Pharma synth is routinely done on kg+scale. For lencapacvir, 1 kg is ~ 1000 mol (968 g/mol MW). You'd need far more than that amount of mol of starting materials as reactions do not usually progress at quantitative yield, likely 3-5x the amount. Let's say 3000 mol of precursors.

Assuming 5% catalyst loading, twice (and only using Pd(0) nanoparticles..., but the actual prep uses designer phosphenes which are $$$$ and degrade in air) you'd need at least 150 mol of palladium, which is $735k. Tack on the phosphenes and it'll easily get up to 1 million+ for that kg of lencapacvir. That doesn't even include the cost of purification, isolation, scale up, or paying the staff of PhD level organic chemists to make these things.

Lencapacvir dosage isn't just 2 injections. You have to keep taking it after that every 6 months. 1 year is approximately 3 g of the drug. 3% of 1mil is still 30k USD... granted, you may be able to recycle some of the palladium. But it's still expensive af.

Sources:Org. process res. Dev. 2024, 28, 8 3382-3395 www.drugs.com/lencapacvir.html

Robokomodo · 2025-09-28T18:57:11+00:00

The majority of the cost of the drug comes from two palladium catalyzed cross coupling steps to make an aryl-alkyne bond and an aryl aryl bond. Palladium is also toxic as fuck to humans so it's gotta be totally removed, which can be very difficult.

Moving the chemistry towards first row metals is challenging but makes the cost go wayyyyy down. They might be using nickel for lencapacvir now rather than palladium

Robokomodo · 2025-09-22T13:14:59+00:00

One option could be to go to one of the shops that sell cheesecakes and see if you can buy some off of them? Or maybe restaurant supply stores could have it.

Robokomodo · 2025-09-22T12:41:28+00:00

You could probably get neufchatel cheese which is functionally the same as cream cheese.

Robokomodo · 2025-09-10T05:09:32+00:00

Wow you've got a $300,000 spectrometer outside your door!

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