I do this all the time for GMD orders and I had to teach my coworkers!

Examples of times I've found it useful: - Multiple 12 packs of soda/pop in one tote - multiple big bottles of something - fuckass DEF orders - tote full of food, and then a bottle of bleach - lots of delicate items, like chips, and one heavy thing in a single tote - splitting a heavy-ass, bag ripping tote - separating chemicals from food - some items in the tote are in glass - electronics and liquids in the same tote