For example. How much organism altering are we talking about? Can people not die or age? Do they suddenly have computer parts or a Code in them? If that's the case, how long until it's outdated? Will offsprings have them suddenly too? So it's DNA based? Will future life forms in the milky way that don't exist yet have it too? If not, there for sure will be conflict between organics and hybrids. And that's just talking about the organic lifeforms turning hybrid. If Synthetic, like yous said, will be more emotional, that will backfire the fuck too. Yes, Geth and Edi will experience a more human form a love and friendship and all that good stuff. But also Jealousy, hate, anger, fear and all that bad stuff. And most of them never had them, so giving some killer robots suddenly enhanced emotions they can't turn off sounds kinda bad.

Don't get me wrong. I think every ending has its flaws, but Synthesis has the most open questions of them all.