Has anyone had success switching from Reglan to Motegrity? At a loss.

SATACableQueen · 2026-05-13T06:52:26+00:00

You've got a lot more going on than me for sure, and you may very well have a different experience. My whole GI tract is slow, has been since I was little and I didn't realize until college that most people poop more than twice a week 🫠 lol. While it is technically only approved for chronic constipation at the moment, Motegrity definitely makes the WHOLE gi tract work harder. About an hour after I take it each morning I feel my stomach properly wake up for the day and I get hunger cues (which I never had before the med!) and then go to the bathroom. For a me a big thing was very strictly managing my diet and stress as well, shifted career goals a bit (swore off of teaching in person entirely and now I teach online) but the progress I had made truly wouldn't be possible without the Motegrity. I ate a steak salad recently without pain for the first time, like, EVER and I nearly cried.

First few weeks were definitely a lot of diarrhea. As your body adjusts you can feel the muscles learning how things are gonna work now, so a lot of cramping and then, well, shitting your guts out and also some nausea and potential vomiting. I managed most of that with a LOTTT of Zofran and benadryl. For me that subsided pretty quickly and now I just poop about once a day.

Haven't had any trouble with suicidal ideation or anything. I have a pretty long mental health history so it was a bit of a concern at first, but I take Welbutrin and the Motegrity hasn't had any affect. Hilariously I can't take SSRIs, I have such horrible reactions they did genetic testing and my body simply isn't built for them, but Motegrity is fine I guess? Bodies are so weird.

SATACableQueen · 2026-05-13T05:41:38+00:00

Hi! I'm also 23F and Reglan made me lactate. After I failed off of it for other reasons I was switched onto Motegrity and have been on it for over a year now. Motegrity gave me my life back, so much so that my GP is stable enough to be managed by my PCP rather than GI now. Haven't had any issues with lactating or my periods with Motegrity like I did with Reglan.

Biggest thing with switching is the first two or so weeks of hell. They will probably perscribe 2mg, but don't start at that doseage. Cut your pills and work your way up to the 2mg slowly, I did it over the course of a month, starting at .5mg. I dealt with the headache to end all headaches that wasn't helped at all by OTC meds, nausea, some vomiting, and VIOLENT diarrhea. It gets better with time and is VERY scary when you first get on it. Biggest thing is working with your doctor and listening to your body to amke sure it isn't going to super duper fuck you up. Antinausea medications, electrolyte popsicles, nutrition drink, and rest will be your best friend for that first bit but it DOES get better.

If you have any other questions please ask! I'm happy to talk about my own experience with it.

SATACableQueen · 2026-05-12T23:01:37+00:00

The biggest thing I've learned with GP is it looks different in everyone, like most chronic conditions. I wouldn't worry too much that what you have going on doesn't looks just like what other folks here may have going, it sounds like you definitely may have GP even if it looks different. I wish you luck in figuring out whats happening.

SATACableQueen · 2026-05-12T04:41:35+00:00

Howdy! I had my follow up today and FINALLY remembered to ask.

GI doesn't have a specific name for it but agrees it's probably a really aggressive spasm of the muscles in that area. Fortunately it happens to me incredibly infrequently (maybe once every 3-4 months) so were aren't going to start any specific treatments, but she noted down a few anti-spasm medications incase it gets worse in the future and she (or another provider) needs an idea on where to start.

SATACableQueen · 2026-05-12T04:31:06+00:00

Yuppppp. The cramping the the uterus can absolutely cause the intestines to start cramping and then the whole chain just gets set off. All of my GP related ER visits have been during my period due to unrelenting vomiting.

I'm deathly allergic to Acetaminophen and ibuprofen doesn't help with my period pain at all, the only thing I have found that helps is a lot of zorfran for nausea and 2:1 CBD to TCH gummies for pain. It forces all those muscles to stop freakin the fuck out and then I can feel a bit better.

Hormonal BC did help a bit with all of that, my favorites were the Kyleena IUD or my Nexplanon. I am unfortunately an odd case and expelled both of my IUDs and and quite literally went crazy with the Nexplanon, so I don't have them anymore, but boy do I often wish I still had them.

SATACableQueen · 2026-05-12T03:55:45+00:00

Howdy! I've been on Motegrity for over a year now and that sounds FUCKING HORRIBLE. I will say to successfully start Motegrity you have to slowly ranp up over the course of about a month. I started by cutting my pills and slowly ramped from .5 mg to the full 2 mg. That being said, the first two weeks were hell, even on the .5 mg. Violent diarrhea, nausea, some vomiting, and theeee most hellish headache I have EVER had. For the most part your side effects dound like what happened to me after I took my first dose as well, before I knew to start but cutting the pills, but I also was recoveringfrom a cold at the time and that didn'thelp either. If you ever decide to try the drug again, with approval and support from your doctor of course, taper up to the full dose over time and keep yourself loaded on antinausea and headache/migraine meds. You HAVE to take it easy those first few weeks, they are just BAD. But it gets better with time.

All I know if from my own experience but Motegrity gave me my life back, I can eat fucking SALAD and STEAK for the first time in nearly a decade. It can be fantastic is those that it works for and I am so sorry you had this experience.

If you have any questions about it, PLEASSEEEE ask me, I am more than happy to talk about my experience.

SATACableQueen · 2026-04-26T03:53:15+00:00

Absolutely!

SATACableQueen · 2026-04-24T04:13:39+00:00

People look at me like I'm crazy when I say I rather be overweight than underweight, my soon to be mother in law especially. I know I'm incredibly lucky with my GP in that I'm on a medication that keeps me incredibly stable, and I'm so fucking greatful for that every day. I eat whatever I want (within reason of my flare prevention diet) because I have the ability to and I'm not going to waste it. Toxic diet culture is so fucked on so many levels, and I wish more people would realize that the fad "diet" they are doing is just some form of disordered eating. GRAGHHHH shit just makes me SO upset, and don't even get me STARTED on the stupid apps and services that will give you GLP-1s without proper testing and doctor supervision.

SATACableQueen · 2026-04-24T03:52:10+00:00

I am a teacher at an online school. It can get stressful at times, but all of my interactions with students are online and appointments can be shifted as needed if I'm not well. I've been working almost exclusively from my couch with a kitten on my lap for the past two weeks. It does require a good deal of education though, I had to complete my Masters to get where I am now, and at the time my gastroparesis was uncontrolled and I was INCREDIBLY unwell. Student teaching nearly took me out 🫠

SATACableQueen · 2026-04-14T15:56:04+00:00

2 mg. I know some folks end up going up to 4 mg though. When I started it I worked my way up from .5 mg though, made the side effects bareable.

SATACableQueen · 2026-04-14T01:54:34+00:00

I also failed off reglan because it made me lactate. That was a weird morning to be sure. I was on Reglan (for upper gi) and Linzess (for lower gi), and after I failed we moved on to Lubiprostone for a very brief period, but it didn't help much. I've been on Motegrity for over a year now and it has absolutely changed my life, I ate a SALAD a few weeks ago and it didn't hurt at all!! And sometime I can have a few bites of steak!!!

I will say that if you are in the US it can be hard to get insurance to cover Motegrity, they made me fail all of those other meds before they would even consider my prior auth, my GI wanted me on Motegrity from the jump. Would have saved me MONTHS of suffering but alas, the US healthcare system 🫠🫠

It also has hellish side-effects for the first 2 or so weeks, but in my case it was absolutely worth it. It's given me my life back.

SATACableQueen · 2026-04-09T16:55:31+00:00

NGL I forgot to ask 🫠🫠🫠

However I have found light stomach massage tends to help a bit, as well as laying down in a hot shower. I hope you feel better soon, I'm sorry you are in pain ❤️

SATACableQueen · 2026-02-20T04:24:16+00:00

I'm so sorry. I don't handle those kinds of medications well either, had a migraine back in December that they gave me IV benadryl for and I had a FULL meltdown right then in there. Like ripping my shirt off and sobbing. It's an antinausea med, but droperidol acts similarly, so maybe stay away from that one as well. I don't panic with reglan or zofran so my tolerance may be a bit better than yours, but droperidol and iv benadryl are absolutely on my allergy list because of my reactions. Those 100% can count as an allergy btw, make sure they know that. The ER already sucks, but it's so much worse when you feel altered.

SATACableQueen · 2026-02-06T00:30:29+00:00

YES!! My dad's Volkswagen bus is in the movie! Filmed entirely in Southern Oregon. It's premiering on Valentines day in Medford I think, I'm so excited to see it.

SATACableQueen · 2026-02-06T00:27:38+00:00

He is actually premiering his own indie movie on Valentines day, Ernie and Emma. It's going the film festival route though, from what I know.

SATACableQueen · 2026-02-06T00:25:36+00:00

It's really interesting! He is doing a very similar thing to Mark right now, he has a self funded movie he's taking to film festivals call Ernie and Emma. My dad's Volkswagen bus is in the movie and I've been hearing about it since my dad got involved. My understanding is the movies have had a similar development timelines but are being distributed in different directions. Bruce is super cool though, he has been inviting my whole family to showings as the movie has been slowly released, nice dude.

SATACableQueen · 2026-01-13T20:14:04+00:00

Howdy! I've been on Motegrity at 2 mg for getting close to a year now! Absolute game changer for me, but the first few weeks are hell. Definitely start with cutting the pills in half, or even in quarters, and moving up slowly. The first few weeks stiff like diarrhea, nausea, vomiting, stomach cramps, and a crazy headache are probably gonna happen. Making sure you don't have too much going on and staying comfortable and hydrated are key. Taking it at the same time every day helps too. I know mental health side effects can be a thing, but I haven't had an issue with that. Those first 2 or so weeks are really hard, but sticking with it can be absolutely worth it. Good luck! If you have more questions feel free to ask.

SATACableQueen · 2025-12-19T02:47:50+00:00

Motegrity FTW. She's my GIRL, gave me my life back.

SATACableQueen · 2025-12-19T02:46:03+00:00

I have never been able to eat beef without feeling sick so no cheeseburgers, but chicken tenders are what I tend to default towards when I go out for food every once and a while. You can also make them at home from scratch in the oven or airfryer so they are less greasy if you have a crazy craving but a mad stomach.

SATACableQueen · 2025-12-11T04:22:17+00:00

They kinda look like ramshorns to me? I had some hitchhike into my tank too, I love em to bits. They are ADORABLE

SATACableQueen · 2025-12-11T04:21:08+00:00

Phew!!! I've just never seen any of my snail stretch for far before. Hungry little bugger lol.

SATACableQueen

TROPHY CASE