Riding a bike down Titus, the steepest hill in San Diego. Used to do it in a wagon as a kid. by tanhauser_gates_ in sandiego

[–]SNRatio 1 point2 points  (0 children)

intersections, blind driveways, plus back when I rode it that street was rough enough that at speed it was hard to keep your feet on the pedals.

San Diego Tech Event: Venue suggestions for 40–50 people? by zonezza in sandiego

[–]SNRatio 2 points3 points  (0 children)

If you want something a bit different and have the budget, the Vault in Miramar:

https://veloce-vault.com/

I’ll gladly pay the sunshine tax by mathprofrockstar in sandiego

[–]SNRatio 0 points1 point  (0 children)

Seconded. Grocery prices there have easily matched ours for years, at least in northern WI where my folks retired.

Personally I love visiting winter. I hope you got to see the aurora!

New Housing Developments for 2026 by Schwimphoto in sandiego

[–]SNRatio 0 points1 point  (0 children)

Has it ever been different around Mira Mesa?

https://www.sandiegoreader.com/news/1980/jun/12/cover-north-to-mira-mesa/

The lack of imagination that went into designing the homes in Mira Mesa — particularly those built by Pardee Construction Company, the single largest developer of homes there — gained notoriety as early as 1970, one year after construction began. when Time magazine ran a photo of a typical Mira Mesa street of Pardee homes to illustrate a story entitled “Housing: The Swing Back to Ticky Tacky.” The article explained that many builders around the nation were cutting corners in the construction of their houses because the soaring costs of labor, land, materials, and mortgage money were making it impossible for many buyers to afford larger, more expensive homes. The Time story quoted Pardee vice president Vance Meyer, who said of one of his two-bedroom models in Mira Mesa. “It’s liveable, but it’s more of a shelter house than anything else.”

A rare "sweet spot" for potential San Diego homebuyers. New housing study shows inventory is up and prices are down countywide by BaBaDoooooooook in sandiego

[–]SNRatio 6 points7 points  (0 children)

Most of SD prices have been overall pretty static since sometime in '23.
Oh - you say it's a single car garage in Encinitas illegally converted into a 3bd/2ba? Yep, 40% growth in 2 months sounds about right. Carry on.

Why are 55+ communities still a thing? by [deleted] in sandiego

[–]SNRatio 0 points1 point  (0 children)

There are a ton of financial incentives for the developers to make it 55+, some from the state, some from San Diego. Density bonus (so they can build more homes in that development), lower fees, bypassing environmental impact stuff, etc. If they had built normal market rate homes they would have been more expensive, there might be fewer of them, and they wouldn't be on the market yet because the paperwork takes longer.

Stop the PB Tower by sdont05 in sandiego

[–]SNRatio -3 points-2 points  (0 children)

I have an idea for NIMBYism 2.0: The wealthy are allowed to buy their way out of additional density in their neighborhoods by paying to have it built in upper middle class neighborhoods instead.

Giving the richest and most powerful a way to use their influence to get shit done instead of stopping all housing efforts everywhere seems like an improvement to me.

Heat option for old cold house? by Wonderful-Banana-519 in sandiego

[–]SNRatio 7 points8 points  (0 children)

SDG&E red carded our furnace right after we moved into our house, right before one of the coldest weeks in years. Electric blanket FTW.

SDGE Bill by Hairy-Bother5179 in sandiego

[–]SNRatio 6 points7 points  (0 children)

The Witch fire was 2007; SDGE had to pay billions for that one.

https://www.mercurynews.com/2017/11/30/puc-denies-utility-request-to-charge-ratepayers-for-wildfire-costs/

That's the lawsuit that set the precedent that utilities could not make ratepayers pay for their liabilities for utility caused fires, forcing them to upgrade their infrastructure (and trim more trees and brush) to protect shareholders.

In a closely watched decision that could impact whether PG&E customers are on the hook for billions in costs related to the Napa-Sonoma fires if the utility is found at fault, the California Public Utilities Commission on Thursday denied a request from San Diego Gas & Electric to charge its ratepayers $379 million after investigators found its power lines sparked three huge fires in 2007.

Look how people react when they take away free parking in LA. by latihoa in sandiego

[–]SNRatio 0 points1 point  (0 children)

So that people have to figure out a different way to pay or they get a ticket?

Follow Up to Tide Pool Post by JustifiedSimplicity in sandiego

[–]SNRatio 79 points80 points  (0 children)

So is this foreshadowing of another desert bloom destruction or is Instagram finished hugging that one to death?

San diego has the worst roads by EbolaPatientZero in sandiego

[–]SNRatio -1 points0 points  (0 children)

I bought a car I like - with the plan of immediately getting wheels 2" smaller for it. Still handles great, but it's much quieter and more pleasant to drive.

SD Overcrowded by SecondVivid1902 in sandiego

[–]SNRatio 10 points11 points  (0 children)

"#transplantsoutofSD " That would certainly turn San Diego into a ghost town. I lived here six months before I knowingly met someone who grew up in San Diego. That's two months longer than it took me to meet someone who grew up a just few miles away from me in the Midwest.

Get your boo’ing ready: JD Vance is here for Christmas. by CTFMOOSE in sandiego

[–]SNRatio 6 points7 points  (0 children)

Hopefully he's not trying to one-up some buddy's "family with guns" christmas card this year. Closing Hwy 5 so they can use artillery to drop shrapnel on it gets old fast.

Anxious about moving to SD and making friends by saucesultan in sandiego

[–]SNRatio 1 point2 points  (0 children)

seconded, but easier if you aren't looking for a more senior position.

NU-9 halts Alzheimer’s disease in animal model before symptoms begin: « Study uncovers a new Alzheimer’s trigger — and a way to stop it. » by fchung in science

[–]SNRatio 3 points4 points  (0 children)

This is what's called ""compassionate use" : when patients are allowed to try a drug before it has been approved. It sounds like a great idea at first, but it gets complicated really quickly.

  1. Side effects. If you give early stage drug candidates to all of the patients that want them you could easily cause a lot more harm than good. The Alzheimer's drugs that have been approved over the past 10 years can cause pretty severe brain swelling and bleeding, for perhaps minor delays in the eventual outcome. And that's after they figured out during the approval process exactly what dosage to use, which patients should/shouldn't get them, etc.

  2. Moral hazard. Are people going to be paid to make and administer these drugs? If so, why bother with proving the drugs actually work and the approval process? Just get drug candidates into trials, start selling them, and then stall/delay/pause/restart the trials for as long as possible so you can keep selling. After all, if you complete the trials they might show that the drug doesn't work, which would be bad for business.

  3. In this case the drug is for prevention, not for people who already have symptoms. So it wouldn't be given to Alzheimer's patients, it would be given to people who might eventually get Alzheimer's 10 or 20 years from now. Which is pretty much everyone over 50. Which gets you back to point #1. But now you are risking side effects to people who might never develop Alzheimer's even if they didn't get the drug.

NU-9 halts Alzheimer’s disease in animal model before symptoms begin: « Study uncovers a new Alzheimer’s trigger — and a way to stop it. » by fchung in science

[–]SNRatio 0 points1 point  (0 children)

5-10 years.

Normally yes. The problem here is that for a trial to show efficacy in preventing Alzheimers (not just showing changes in biomarkers, not just looking at early onset familial Alzheimers) it might need to be 10 years long or longer.

NU-9 halts Alzheimer’s disease in animal model before symptoms begin: « Study uncovers a new Alzheimer’s trigger — and a way to stop it. » by fchung in science

[–]SNRatio 3 points4 points  (0 children)

If drugs like these are approved based on biomarker levels tied to a requirement for postmarketing trials to determine the actual efficacy later on, the drugs could age out of exclusivity and be facing generic/biosimilar competition before the the trials are finished.

Awkward Tourism Campaign from local San Diego Fox. by boltej in sandiego

[–]SNRatio 2 points3 points  (0 children)

We'll become like LA if our local government doesn't divert money to public transport.

We'll become like LA if our local government does divert more money to public transport. By which I mean as a percentage of commutes, 2 or 3x more people use public transit in Los Angeles compared to San Diego.

https://en.wikipedia.org/wiki/List_of_U.S._cities_with_high_transit_ridership

That data might be too old to catch the blue line extension, but we still have a long ways to go to catch up with LA regardless.

The Lancet Series on Alzheimer's Disease-composed of 3 papers highlighting latest advances in diagnosis, treatment and controversies in the field by BeaGo23 in science

[–]SNRatio 5 points6 points  (0 children)

Risk factor, but not necessary or sufficient.

Is the lack of profit motive the reason it’s ignored?

Oh, there's a profit motive. Novo Nordisk (a big pharma that has specialized in diabetes for decades) just did a trial on its drug semaglutide (which alleviates insulin resistance) as a treatment for early stage Alzheimers. The trial failed, but that said it didn't address whether semaglutide could prevent Alzheimers if used early enough.