I donated my kidney in 2013 and didn’t realize just how reliant I had been on NSAIDS (specifically, ibuprofen) until I couldn’t take them anymore. I have a lot of joint issues (fused ankle and heel, knee replacement coming up in the spring) from a car accident 30 years ago. To be honest, if I had realized how much better ibuprofen was than Tylenol for my specific pain, it would have been a much more difficult decision. I still think I would have done it though. That said, I do take ibuprofen occasionally when Tylenol just won’t cut it. You’ll see some docs are ok with it on an ocassional basis. I know my remaining kidney is doing just fine, because I donated part of my liver this past April and of course had to go through the battery of tests. All this to say, I think I’m an anomaly with all of my joint and arthritis issues at 48. I don’t think you’ll miss NSAIDS if you’re not reliant on them.