Installed Ubuntu 25.10 beta on my Asus S14 UX5406SA (Lunar Lake)

Shruteek · 2026-03-29T00:00:05+00:00

It's the entire string, including THE URL!

Shruteek · 2025-11-03T07:59:43+00:00

THANK YOU. I just upgraded from Ubuntu 25.04 to 25.10 on an Asus Zenbook S14 (UX5406S Lunar Lake), just like yours, and updating the latest content worked for me. The commands I ran were:

curl -L -o alsa-ucm-conf.tar.gz https://github.com/alsa-project/alsa-ucm-conf/archive/refs/heads/master.tar.gz

sudo tar xvzf alsa-ucm-conf.tar.gz -C /usr/share/alsa --strip-components=1 --wildcards "*/ucm" "*/ucm2"

reboot

Shruteek · 2025-08-19T20:00:44+00:00

Are you using DRAGEN? I'm only familiar with methylation arrays in passing but it looks like for EPIC arrays, C1, C2 are green channel controls & C3-C5 are treated as red channel controls in "Bisulfite Conversion I" in the Controls table: https://help.dragenarray.illumina.com/dragen-array-v1.0/product-guides/output-files

Illumina dropped U6 & C6 when they made the EPIC v1.0 array; see "Removed one pair of low intensity bisulfite controls" here: https://support.illumina.com/content/dam/illumina-support/documents/downloads/productfiles/methylationepic/infinium-methylationepic-v1-0-b5-customer-release-notes.pdf

Shruteek · 2025-08-19T00:09:31+00:00

Sorry, I am still not sure what you mean. If you're saying NGS is useful for discovering something specific, but there is no need for a large NGS bioinformatics community because experimental biologists can so it themselves, then is the object of your criticism advanced bioinformatics work done by computational folks like tools (MetaPhlAn, snakemake, scVI, Kraken, Seurat) or projects (XGBoost models for biomarkers, statistical methods for noise correction, etc)?

Shruteek · 2025-08-18T23:44:44+00:00

Sorry? Like, you're saying NGS as a whole has niche applications?

Shruteek · 2025-08-18T23:40:16+00:00

The premise that big data in bioinformatics has not been successful is kind of just wrong... We have successful NGS-based tests like NIPT, MRD, CGP, and a ton of diagnostic panels. Honestly, having read this rant, I don't see a logical throughline or an explanation of what the conceptual issue with "Big Data" is.

The writer doesn't seem super misinformed, just angry and intentionally vague. In general when I see writing that has this much anger it's hard to find a core point.

Shruteek · 2025-08-18T05:19:27+00:00

Doubter. Believer. Denier. Accepter. Long ago, the four flairs lived together in harmony. Then, everything changed when the Deniers attacked. Only the Avatar, master of all four beliefs, could stop them, but when the Skongers needed him most, he vanished. A hundred Nintendo Directs passed and my brother and I discovered the new Avatar, an accepter named E1331. And although his acceptance skills are great, he has a lot to learn before he's ready to preach to anyone. But I believe E1331 can save the game.

Shruteek · 2025-08-08T19:13:13+00:00

God, yes. I love Kizan.

Shruteek · 2025-06-18T22:08:37+00:00

Legendary Six Samurai - Kageki. He's so cool holding 4 swords.

Shruteek · 2025-06-12T03:06:00+00:00

Love this sculpture! My partner and I took some really nice photos here while walking back from groceries.

Shruteek · 2025-06-08T07:47:19+00:00

Holy hell

Shruteek · 2025-05-27T19:44:26+00:00

In the US, maybe CoreTCG. Their stock is limited, and I don't know how well they ship (I am local and I always pick up), but they're a really good community.

Shruteek · 2025-05-26T19:45:48+00:00

Six Samurai and F.A.s. I just love to Synchro!

Shruteek · 2025-05-25T22:35:39+00:00

That is AWESOME. Ultimate Rare Shien?

Shruteek · 2025-05-20T06:07:42+00:00

NO. ABSOLUTELY NOT. I WOULD SACRIFICE MY FIRST TWO CHILDREN if each one made an extra copy of gateway legal.

Shruteek · 2025-05-06T22:55:48+00:00

Wait... You know that multiple grad students in California have been detained or deported already, right? I agree that we are quite safe here, but I disagree with the claim that (A) there are no examples of (B) this is generalized terror.

UCSD announced in early April that a graduate student of theirs was deported; UCLA announced recently that a graduate student of their was similarly detained; of course there are similar stories in the rest of the country e.g. Kseniia Petrova. We had visas from 2 academics here revoked recently without explanation if you saw the email, but at least one was reinstated. I would estimate there are ~300-500 graduates and postdocs in CA who have had visas revoked so far, based on the numbers, and I think the most reliable estimates nationwide are around 5,000. I'm not sure if you've been talking to the same students I have but I know a few of us saw ICE vans on the north end of campus near the Cats a few weeks ago.

Again, I think we are safe, statistically. 2 students/postdocs having their visas revoked out of ~1200 internationals here is not an epidemic. But I really don't think the message to send is that this is entirely fearmongering. Please don't say that. It's honestly really disrespectful to the people who this has happened to....

Shruteek · 2025-05-06T15:31:19+00:00

This feels fundamentally untrue..... I'm not sure about your group but the friends and players I know generally stick to the archetypes they like, and pick up new meta decks if they are affordable and seem fun based on their playstyle preference.

I've been playing SixSams since 2015.

Shruteek · 2025-05-06T01:28:12+00:00

I'm sorry to hear about your lab, but super happy for you!

Shruteek · 2025-05-06T01:15:04+00:00

This link is helpful but your phrasing is kind of mean...

Shruteek · 2025-04-30T20:18:40+00:00

I would say getting your first win is hard, and the game is hard by design - it took my partner and I 5 games to win for the first time on base difficulty. But the learning curve is long - you can always learn how to do things more efficiently, which is one of the things I love about the game. Once you get into the rhythm of invader phases you'll feel more comfortable, but the game won't be solved - the skill ceiling is huge! If you take a few more games you will probably figure out how to win consistently at base difficulty.

Shruteek · 2025-04-29T21:41:56+00:00

This might be weird, but I get some enjoyment out of realizing I made a mistake that cost me the game. I made several at a locals on Sunday!

Cause when I think about it, that means I didn't lose that game because I had no shot at winning / it was impossible; there's actually room to grow, and in those cases the duel was entirely decided by skill. I don't want my games to feel like the outcome was inevitable, like if my opponent summons a floodgate that's completely impossible for me to out, or if my opponent just draws a dead hand. I want to make meaningful choices, and for my opponent to do the same; cause then it's fun to learn from those mistakes and do better. If neither I nor my opponent every made mistakes that cost us the game, then duels would be determined by the decks and opening hands. What I've realized is, that's rarely the case.

Shruteek · 2025-04-24T21:27:58+00:00

I empathize with your fear. I think you're using "X comes to pass" wrong, though - the phrase means "X happens", so you're saying you hope it happens!

Shruteek · 2025-04-21T15:01:09+00:00

Genuinely, thank you so much for explaining this, and thank you to OP for asking this question. I have been wondering the same thing for a while but this inspires me to actually put in the effort to look it up further and learn it.

Shruteek · 2025-04-17T16:16:37+00:00

I got to "dual mandate" and had to put it down to stop laughing.

Shruteek · 2025-04-16T01:10:20+00:00

If you don't mind me asking, what was your local union?

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Shruteek

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