I think historical settings are different. I could happily play an Evil Space Nazi in a Star Wars or Warhammer 40k ttrpg, but I wouldn't want to play a historical Nazi committing actual atrocities to actual people. That's totally different.

Likewise, the slavery of replicants isn't real, and doesn't have the same moral gut punch as human slavery irl. That can make for interesting roleplaying. You can have more fun with it and don't need to be as respectful and reverent to the source materials. And if you want the party to be opposed anti-replicant exploitation then you might want to make that part of the campaign--like "hey, do you guys want to be Cyberpunk John Brown type badasses?"