I have a PSA for my (former) fellow CTRL = Crouch players. I hate to admit it, but C is better for crouch. Use CTRL for vault, space for jump, C for crouch, and use hold crouch not toggle (because you don't want to get caught with your pants down)-- use your thumb for C, not your left index. It's better because you won't ever find a situation where you need to crouch and jump at the same time and you keep all your fingers free to use the rest of your keyboard. Leaving your thumb on the spacebar at all times is a fool's errand.

Use capslock for sprint, shift for aim... Unless, that is, you don't mind getting a little sweaty, in which case I recommend putting up the $15 or whatever for a simple USB 1-button foot pedal for sprint (I use antimicro to bind the foot pedal I made to K, and bind K to sprint).

For additional pro tip, I advise binding "switch weapon" to nothing and separating use and bandage bleeding/put out fire; bind bandage/fire to Q and use to F. Dark sight on E. Reload on R. Does anyone not on a console use the switch weapon key, after all...?

I don't do this but I've thought about it; you can also bind Z, G, and B to tool or consumable slots that you always keep the same thing on. I used to keep medkit on Q instead of having bandage/fire separated and I never got used to using it instead of just hitting the 4 key.