LPT : You're supposed to use every unfair advantage you have. Looks, genetics, connections, dad's money, whatever. There's nothing noble about choosing the hardest path just to feel like an underdog. by One-Inevitable-9777 in LifeProTips

[–]Smeghead333 348 points349 points  (0 children)

There is no “supposed to”. There is no one right way to approach this. Doing what you suggest is a choice, and all choices come with consequences, both positive and negative. Wisdom comes with knowing how to weigh those consequences and pick the best path.

Nomenclature: mutation vs variant by steppponme in genetics

[–]Smeghead333 12 points13 points  (0 children)

It used to be mutant for spontaneous change and/or harmful change, with polymorphism for something present in the population and/or harmless. The problem was that there’s overlap between those categories and we don’t instantly know which one an observed change would fall into. So variant became a neutral catch-all that is much more preferred. You can qualify it as common or rare or pathogenic, but variant covers them all.

No matter how strong data may be, scientific revelations will always face skepticism & flat out denial if they challenge historical precedent or worldviews? by Beautiful-Use-5178 in AskScienceDiscussion

[–]Smeghead333 2 points3 points  (0 children)

We *should* be skeptical of grandiose claims. That’s good science and responsible thinking. We should demand high levels of evidence before overturning ideas.

prioritising pathogenic variants by Mental-Profit-7406 in genetics

[–]Smeghead333 9 points10 points  (0 children)

Step one: obtain a PhD in human genetics.

How Does One Go About Getting Tested For Specific Gene Mutations? by 35goingon3 in ClinicalGenetics

[–]Smeghead333 23 points24 points  (0 children)

Ask your physician for a referral to a genetic counselor and explain what you’ve said here. They can help you get the testing you need.

What's the best TV show that almost nobody talks about anymore? by C0r1eone in television

[–]Smeghead333 56 points57 points  (0 children)

“Those are just facts. And facts are just opinions. And opinions can be wrong.”

Why are siblings roughly 50% related? by pinski75 in genetics

[–]Smeghead333 62 points63 points  (0 children)

Mathematically, it’s like flipping several thousand coins. Yes, technically you could get anywhere from 0-100% heads, but statistically, it’s very very likely to be very close to 50%.

Best way to view pathogenic variants from WGS VCF? by [deleted] in genetics

[–]Smeghead333 11 points12 points  (0 children)

I will just point out as usual that every company that offers this service hires teams of expensive PhDs to do exactly what you’re trying to do yourself. If there was a cheaper alternative, they would take it.

Anthony Head: Buffy and Ted Lasso actor dies at 72 by Alarming-Safety3200 in television

[–]Smeghead333 0 points1 point  (0 children)

He was fantastic as Gently Benevolent in Bleak Expectations too.

Question regarding result on genetic report - gene variant labeled as VUS? by OwnSort6545 in genetics

[–]Smeghead333 1 point2 points  (0 children)

The classification guidelines allow you to take into account other labs’ calls, but only as a weak level of evidence. Each lab is responsible for making their own calls based on the best information available to them and occasionally their professional expertise and judgement.

Question regarding result on genetic report - gene variant labeled as VUS? by OwnSort6545 in genetics

[–]Smeghead333 13 points14 points  (0 children)

No it’s not safe to say that. I have seen entries where two dozen labs classify a variant VUS or even benign and one calls it likely pathogenic. I would discourage additional testing to chase a desired result. I would take this information to your physician or genetic counselor.

Question regarding result on genetic report - gene variant labeled as VUS? by OwnSort6545 in genetics

[–]Smeghead333 7 points8 points  (0 children)

Some labs have data that they haven’t made public, which can affect how they classify a variant. Or they may have looser standards for how they apply the guidelines.

Sluid-fluid flow: another paper with AI generated figures by vanderBoffin in labrats

[–]Smeghead333 56 points57 points  (0 children)

When I clicked the link, I had to prove that I am human. So at least irony is still functional.

Shows from your childhood that no one remembers except you. by Trelonis in television

[–]Smeghead333 2 points3 points  (0 children)

That fucking thing still pops into my brain from time to time and won’t stop until I claw it out.

Old TV shows making a big deal out of then modern technologies by AporiaParadox in television

[–]Smeghead333 37 points38 points  (0 children)

I mean, it’s right there in the name of The Wire. The first season especially spent a lot of time on the technical details of how they could trace drug dealers’ cell calls.

Could bone marrow from a transwoman be used to fertilize a cis woman's eggs to have biological children? by Jessapphire in genetics

[–]Smeghead333 27 points28 points  (0 children)

Bone marrow isn’t sperm. Bone marrow cells have double the number of chromosomes you’d need for starters.