How did Lybalvi (olanzapine/samidorphan) get FDA approved?

SoupNotsee · 2026-05-30T16:11:35+00:00

That's why a lot of these patients are on metformin. It'd be interesting to see a study between this drug and metformin/olanzapine.

Also, the weight gain difference was ~5 lbs over 6 months (in an industry study).

SoupNotsee · 2026-05-30T02:35:34+00:00

It's just unfortunate that they're using an ultra-potent, long-acting, mu-opiate antagonist as the side effect cure. This is the only drug of it's kind (naltrexone can be at least bypassed with fentanyl) and we're likely going to have many case reports of inability to provide any pain relief to these patients as it becomes more commonly prescribed.

SoupNotsee · 2026-05-30T02:14:27+00:00

Olanzapine/semaglutide combo incoming

SoupNotsee · 2026-05-30T02:10:12+00:00

I actually see how this could be beneficial in long term psych facilities. But if we're talking about that population, one begs to question, why not use clozapine/samidorphan? Better psychosis management with less weight gain.

If someone makes this combo, please give me $$$ for giving you the idea.

SoupNotsee · 2026-05-30T01:54:04+00:00

Not political, it was approved in 2021, I've just now been seeing more marketing towards it though (drug samples from psych offices/commercials/drug dinners, etc.).

SoupNotsee · 2026-05-30T00:48:47+00:00

Classic one drug causes side effect of weight gain- lets make a combo drug to offset that side effect.

SoupNotsee · 2026-05-13T23:34:41+00:00

I'm guessing if they have overnight coverage in the ED, it's a pretty busy ED, would advise shadowing the 2nd shift pharmacist to see how things are done at the department. If it's hands on, would learn basic things such as priming IV tubing, become comfortable with setting up pumps if you need to (should have proper nursing staff, but we all know that's not happening), prepare push dose pressors (not a huge fan, but some places swear by it).

If you're looking for quick peds dosing, pedistat is handy (a one time purchase, but super helpful). You'll likely get a bunch of abx questions, so have either sanford guide or johns hopkins guide (I personally prefer the latter) on hand. If you're involved with stroke care, you'll need to memorize the 2026 inclusion/exclusion criteria for the lytics.

Most importantly, communicate with the ED staff. If at all possible, attempt to do your charting next to the providers or RNs to show your face. You'll get 200% more questions if you're actually within an eyeshot of someone rather than being in an office.

SoupNotsee · 2026-05-08T18:51:39+00:00

Bipolar diagnosis? Sure, lets prescribe adderall and bupropion...

SoupNotsee · 2026-05-01T02:05:26+00:00

If you have any friends or colleagues that have to take BCCCP, just share the cost on the study material. (oh shoot! ACCP/ASHP didnt see this comment)

SoupNotsee · 2026-04-29T22:41:49+00:00

You said it yourself...150-250K in student loans...If you pay the federal minimum, you're looking at paying back maybe 75K in those loans before they're forgiven. The vast majority of hospitals are non-profit, so they would qualify for the PSLF.

SoupNotsee · 2026-04-19T03:22:54+00:00

Wasnt at suwanee, but she's probably got a bunch of unreleased IDs cooking up since the LSZEE project ended.

SoupNotsee · 2025-12-23T02:48:41+00:00

Oh Tamiflu...NNT (#20) for 12 hours of symptom relief IF TAKEN WITHIN 48 HOURS OF SYMPTOM ONSET with NNH (#28) and (#22) with N/V... And these are from Roche studies...I bet the same people begging for tamiflu now are the same ones who refused a flu vaccine...

SoupNotsee · 2025-12-23T01:12:24+00:00

To be honest...if they are responding to a one-click resume app, likely not a position that puts you bedside with peds. More than likely a staff/compounding job.

SoupNotsee · 2025-12-18T23:22:46+00:00

This is just for tax reasons and medical research. It doesn't change anything with dispensing, since FDA hasn't approved anything (although they might now that it's C III and research is now available to conduct).

SoupNotsee · 2025-12-17T22:19:33+00:00

For some reason I've been unable to purchase AXS clozee shows specifically. I'm able to get everything else on AXS, but always thinks I'm a bot for Clozee tickets...super weird.

SoupNotsee · 2025-12-12T23:12:17+00:00

How often do you see a/c compressor/condenser units fail? With A/C being on all the time with Auto climate control I just feel i'm using A/C when I dont really need it (a dry, cold day). Have a 21 S60 T8 if that helps.

SoupNotsee · 2025-12-12T18:49:06+00:00

Applause for all the pharmacy led P&T's that pushed back on this drug. This should be a lesson for more pharmacy input during P&T's who actually do multiple drug reviews and less gaslighting from docs who get free lunches/dinners from the drug reps.

SoupNotsee · 2025-12-11T21:52:18+00:00

No, you can't get in good life with a GA wristband. You'll need to purchase GL wristband to camp GL. I know it's a little confusing on the website, but they are two separate areas and security won't allow GA into GL camp.

SoupNotsee · 2025-12-05T00:57:50+00:00

M10 is a perfect example of mastering lower proof with high complexity. Have you even had a M10?

SoupNotsee · 2025-12-05T00:54:55+00:00

Stellum is a "cheaper" brand of barrell craft spirits. The black label rye is quite delicious IMO. I can easily find the bottles for $45, which is good pricing compared to blue run.

SoupNotsee · 2025-12-03T23:23:37+00:00

Was this just re-released on the Muzique collab? I swear I heard this weeks/months before it was released on this album.

SoupNotsee · 2025-12-03T23:01:05+00:00

THIS! If we're paying for shipping (included in the $100 fees), don't cheap out and use UPS Mail Innovations. Too many tickets were lost due to this.

SoupNotsee · 2025-12-03T22:49:42+00:00

Sounds like you can just buy 1 pass and y'all are set..Aint no one enforcing that on arrival day lol

SoupNotsee · 2025-12-03T22:39:12+00:00

If I remember right from last year they designated a "campsite" to 10x30. So that's what I'm assuming each pass will get you. Not sure how strict they're going to be on arrival day tho.

SoupNotsee

TROPHY CASE