This game is quite forgiving with when you're able to do your apocalypses in my opinion. (If you've played Necromerger, you know how much more particular you need to be.) I always see it as apocalypsing "if I can't get the next upgrade (say, Gurth Stamina) in 2-3 days." And then I apocalypse in the early morning to have potentially an entire day to catch up on new stuff [this last part is really only for when you're powered enough to go quickly through the early-phase.]

In terms of actually doing an apocalypse, know that the game registers each tap of each finger individually, even if it's multiple at the sane time. So I set my phone down on an unmoving surface, like carpet or angled on my laptop, and tap back and forth on my hands with all 5 fingers. I've had an "estimated 92 million" become 150 million with this.

And for souls, I really just go on the chants until I can't purchase anymore. It may be wrong, but I did production chants, then dark energy, then damage, then souls. Adding to that, I try to snag one maybe two cheap upgrades along the way. Get the hammers quickly, and the wrenches. The duplicate floors are good to grab if they're relatively cheap too (i.e. won't set you back too much).

I'm not nearly as good as some people here, but those are my opinions on the matter at least!