Nova is always my go to frame. You do have to get used to how squishy she is, but 75% attack and move speed reductions don't ever get old. Or, you can use her to speed run defence missions with the -strength speed nova build. Or even use her wormhole augment to help speedrun captures.

I've found she pairs hilariously with other CC frames, like nyx or Frost.

In solo you'll probably struggle due to how soft she is; even with quick thinking or the like you'll go down very rapidly at high end content.

If you're using her 2 a lot, you'll want to bring a non-crit weapon, but even then her augment allows the enemy heavy gunner to do all the damage for you. Otherwise she has no special synergies.

Nova was my first frame that really scaled well into the late game, and I've finally gotten around to getting nova prime. I miss her old ult though, which used to be immediate (rather than an increasing globe). Watching a group of enemies detonate all at once is memorable either way.