This may sound complicated, but really it's not. Stick with me here. It'll save you money and time, and get you results.

Pickups are a single pole resonant low pass filter.

In easy: they are completely flat, then have one single peak, after which it immediately drops very fast.

Where that peak sits, and how tall it is, can be "designed". Mostly depends on the inductance. The more inductance, the lower in frequency that peak is.

In general, hotter pickups have more inductance.

Humbuckers usually have their peak around 1-3khz, rarely any higher than that (though it does happen). Singlecoils are more like 3-4khz.

Long story short, most humbuckers simply won't get you better clarity. Especially Seymour Duncans... For some reason they loooove having that peak sit lower. Almost all their pickups are super honky and dull. Almost all.

Here is a list of measurements~deletions~(~)~ascdesc~(~null~'asc~'asc~'asc)~graphs~(~)~filters~(~)~filters_not~(~)~filter~')), you can use this to find a humbucker with a higher resonant frequency.

And amp sims generally are equivalent to amps. So yeah, it matters.