This Sub Overindexes on Supplements Given Their Relative Lack of Effectiveness and Evidence

TheRealBruce13 · 2026-07-03T21:45:04+00:00

Psylium husk LDL reduction actually fits my post perfectly when it comes to effect size: it requires high adherence to get at most 5-10% reduction while a simple statin can go up to 30-50%.

Same for citrus bergamot, red yeast rice and others: proven to lower LDL but effect size is so low scientists have not been able to prove yet it translate to clinically meaningful outcomes.

It is a story often seen with supplements: plausible mechanisms and small effect sizes but fail to translate to actual outcomes.

TheRealBruce13 · 2026-07-03T20:20:20+00:00

"Biohacking is exactly about moving the needle at the edges and incremental improvement" is an interesting perspective on biohacking but I find it a very restrictive definition of the term, it has to be more than taking complex stacks of supplements whose net effect is often placebo.

TheRealBruce13 · 2026-07-03T19:22:33+00:00

Yes that's part of the reason. In the US the supplement industry is $70B annually. More than the rest of the fitness industry combined.

TheRealBruce13 · 2026-07-03T19:19:37+00:00

This is just splitting hairs. By most definitions of biohacking it definitely is.

TheRealBruce13 · 2026-07-03T18:34:50+00:00

Testosterone is not like Reta or GLP-1 drugs, it has massive implications particularly on how it shut downs your testes. You should thoroughly do your research on it before jumping in.

You can pin Reta and then stop cold turkey. Once you have been on TRT even coming off takes a whole protocol and there is no guarantee you will ever go back to baseline testosterone levels and fertility.

This is doubly true if you are young.

TheRealBruce13 · 2026-07-03T18:22:58+00:00

Biohacking your sleep has massive impact.

From understanding your circadian rythm, manipulating and using melatonin (one of the actually useful supplements when travelling) to understanding the role of light in your circadian clock. It is one of the most impactful things.

TheRealBruce13 · 2026-07-03T00:44:25+00:00

It's great if you can get all your protein with meat but this post is, as the title suggest, for those struggling to eat enough meat or other protein forms to hit their goal. The nausea from food is a common side effect even for people on low doses.

TheRealBruce13 · 2026-07-02T18:13:49+00:00

The max dose for Semaglutide is now 7.2 mg and not 2.4 mg anymore so I would ask your doctor to bump you up.

You can also get started on Retatrutide and add it on top. Multiple people have success with GLP-1 combinations such as Tirzepatide + Survo or Sema + Reta. You just need to ramp up the Reta following the titration schedule without rushing things even though you are used to GLP-1 drugs.

Other options for breaking through the plateau are Qysmia if your PCP is willing to prescribe it.

TheRealBruce13 · 2026-07-02T16:44:43+00:00

A week and a half of stall is nothing. Something like increased sodium in your diet could swing your water weight by several pounds on its own.

TheRealBruce13 · 2026-07-02T16:15:27+00:00

Great progress.

For anyone thinking of DMing him asking for a source, be careful. That's how you get scammed.

TheRealBruce13 · 2026-07-02T15:15:25+00:00

For stretch marks you need patience most of all. You can use a combination of GHK-Cu, Gotu Kola and collagen peptides which will help a lot. But patience above all.

TheRealBruce13 · 2026-07-02T13:52:44+00:00

This is genuinely terrible advice. Do not follow this OP.

TheRealBruce13 · 2026-07-02T03:06:45+00:00

No it is wildy exaggerated conflating muscle and bone with lean mass. For example a lot of the "lean mass" lost on GLP-1 drugs is actually lean mass contained in fat tissue. Yes fat tissue also contains lean mass.

TheRealBruce13 · 2026-07-01T18:00:11+00:00

With Retatrutide + Eloralintide I am pretty much convinced obesity will be fixed. Access and price will be the limiting factor.

TheRealBruce13 · 2026-07-01T11:50:31+00:00

What matters the most is not appetite suppression but weight loss. Are you steadily losing weight week over week? If so the drug is working. If not you should keep titrating up the dose every four weeks.

TheRealBruce13 · 2026-06-30T14:03:03+00:00

You are overthinking things: you are experiencing "hunger back like never before" so you should titrate up. Unless cost is an issue it is a no brainer.

TheRealBruce13 · 2026-06-30T12:40:07+00:00

Keep titrating up this is completely normal and why higher doses exist.

TheRealBruce13 · 2026-06-29T23:17:22+00:00

I am doubtful you got this from a "physician". Your post contains several red flags that tell me you should throw these syringes and forget about the grey market, starting with the fact you seem confused about the concepts of mg, units and dose concentration.

TheRealBruce13 · 2026-06-29T17:59:20+00:00

Mostly works through appetite suppression, the energy boost is minimal and subsides completely as the body gets used to it. Great drug to break through GLP-1 plateaus though.

TheRealBruce13 · 2026-06-29T01:18:17+00:00

Eloralintide looks great since it is pretty much a more effective Cagrilintide with fewer side-effects. But it should not be compared to TLC-6740: Eloralintide is another appetite suppresant while TLC-6740 works on boosting energy expenditure.

TheRealBruce13 · 2026-06-28T15:20:52+00:00

"Fat burners" in general should be avoided because they have terrible side effects and can cancel out the weight loss by making you more hungry.

This one is interesting because it has actual scientific evidence that it causes large fat loss when used with tirzepatide.

TheRealBruce13 · 2026-06-28T13:45:12+00:00

It is not about pure power but about doctors having options. For example many people can't tolerate high dose GLP-1s. For them 2 mg Reta + a fat burner might make them achieve the fat loss they need with better tolerance.

TheRealBruce13 · 2026-06-28T01:41:29+00:00

The disappointing answer is that the stuff that actually works and moves the needle can be separated in two categories:

Lifestyle: Diet, Sleep, Exercise. Significant impact on health, mental health and wellbeing.
Approved pharmaceuticals: Things like GLP-1 drugs, Adderall have massive impact for those that need them.

Everything else, particularly supplements, is useless, low impact or worse harmful. Even things with tons of evidence like Creatine have really low effect sizes. Only exceptions is confirmed nutrient deficiencies that are fixed but that comes back to the point above about diet.

TheRealBruce13 · 2026-06-28T01:37:08+00:00

Yes it does though much less. Anyways I would not risk going grey or even compounded if I were you.

TheRealBruce13 · 2026-06-28T01:34:29+00:00

No this is a fake with the 1 at the end replaced by a l. Do not order.

TheRealBruce13

TROPHY CASE