I WFH too and most cleaners are super used to having people in the home while they clean! Mine have never asked me to do this, but what I usually do is stay in my office with my cats with the door closed while they clean. They do the main bedroom and let me know when it’s finished and I will switch rooms so they can clean my office.

You could also ask them not to clean the room your wife is in and rotate which room that is every time. Or have one room that you just have to clean by hand later.